3ohglutarateamnscnc

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of 3-hydroxyglutarate in amniotic fluid to detect a rare genetic metabolic disorder called glutaric acidemia type I before birth.

Quick summary

{"Measures 3-hydroxyglutarate levels in amniotic fluid collected during amniocentesis","Used for prenatal diagnosis of glutaric acidemia type I (GA-1)","Important when there is a family history of this metabolic disorder","Helps doctors plan early treatment to prevent complications","Results help parents and healthcare teams prepare for special care needs"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC: 69850-6
Short code: 3OH-Glutarate Amn-sCnc
Synonyms: 3OH-Glutarate Amn-sCnc
Category: chemistry
Sample: fluid
Container: Sterile tube
Units: N/A
Fasting: false
Population: adult
Sex: all
Age range: 18–65 years
Specimen volume: 2-5 mL
Stability: Room temperature: 2h, Refrigerated: 24h
Hemolysis max: 300
TAT: 4–24 hours
Order: routine

What is this test?

The 3-hydroxyglutarate test measures the amount of a substance called 3-hydroxyglutarate (3-HGA) in the amniotic fluid that surrounds an unborn baby. Amniotic fluid is collected through a procedure called amniocentesis, where a thin needle is used to withdraw a small sample of fluid from the womb. This test is specifically used to find out if a developing baby has glutaric acidemia type I (GA-1), a rare inherited metabolic disorder.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Why is this test recommended during pregnancy?

This test is typically recommended when parents have a known family history of glutaric acidemia type I, or when previous children have been diagnosed with this condition. It allows for early diagnosis so that treatment can begin as soon as possible after birth, which significantly improves the child's long-term health outcomes.

Is the test procedure safe?

Amniocentesis, the procedure used to collect amniotic fluid, is generally considered safe but carries a small risk of complications such as infection, bleeding, or miscarriage. The actual risk is very low (less than 1 in 1,000 to 1 in 500). Your healthcare provider will discuss all risks and benefits with you before the procedure.

What happens if the test results are positive?

If elevated 3-hydroxyglutarate is detected, it confirms that the baby has glutaric acidemia type I. A genetic counselor and metabolic specialist will meet with you to discuss the diagnosis, treatment options, and long-term management. Treatment typically includes a special low-protein diet, L-carnitine supplementation, and close monitoring to prevent metabolic crises.

Can this condition be treated?

Yes, while there is no cure for glutaric acidemia type I, it can be effectively managed with early and lifelong treatment. Starting treatment immediately after birth, including a specialized diet that limits certain amino acids, can help prevent the buildup of toxic substances and significantly reduce the risk of serious neurological complications.

How accurate is this test?

This test is highly accurate for detecting elevated 3-hydroxyglutarate levels, which is a reliable indicator of glutaric acidemia type I. However, genetic testing may also be recommended to confirm the specific gene mutations responsible for the condition.

Sources

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy