Complete Blood Count (CBC): What It Is, Why It's Done, and What the Results Mean
This test detects 6-monoacetylmorphine (6-MAM), a unique metabolite of heroin, in your blood to determine recent heroin use.
{"Detects heroin use within the past 24-48 hours","6-MAM is specific to heroin and confirms heroin use specifically","Used for addiction treatment monitoring or substance abuse evaluation","Requires a blood draw at a laboratory or clinic","A positive result indicates recent heroin use"}
Key facts at a glance
- LOINC
- 14844-5
- Short code
- 6-MAM
- Synonyms
- 6MAM SerPl Ql
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube; alternatively, plasma collection tube (EDTA or sodium fluoride)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Immunoassay (IA) with Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) confirmation
- CPT
- 80307 (Drug test(s), per compound, any method); 80306 (Drug test(s), per specimen, initial screen)
- SNOMED
- 373549009 (Heroin measurement); 78563009 (6-monoacetylmorphine)
- Specimen volume
- 1-2 mL serum or plasma
- Stability
- Room temperature: 7 days; Refrigerated (2-8°C): 14 days; Frozen (-20°C or below): 30 days. Protect from light.
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
A complete blood count (CBC) is a common blood test that measures the cells circulating in your blood, including red blood cells, white blood cells, platelets, hemoglobin, and hematocrit. It gives your healthcare provider a broad picture of your overall health and helps screen for a wide range of conditions, from anemia and infection to bleeding disorders and certain blood cancers.
The 6-MAM test is a blood test that looks for 6-monoacetylmorphine (also called 6-MAM) in your serum or plasma. 6-MAM is a substance produced when your body breaks down heroin. Unlike other opioid tests that may detect many different opioids, 6-MAM is unique to heroin use, making this test highly specific for determining if someone has recently used heroin.
You might need this test as part of a routine checkup, or because you have symptoms such as fatigue, weakness, fever, easy bruising, or unexplained weight loss. It is also used to monitor an ongoing condition like anemia or a chronic infection, to check how treatments such as chemotherapy or certain medications are affecting your blood cells, and to evaluate your health before surgery.
Your healthcare provider may order this test for several reasons: to monitor your progress in a substance abuse treatment program, to evaluate suspected heroin use, for pre-employment or legal/occupational testing, or as part of a comprehensive drug screening panel. It may also be used in emergency situations when healthcare providers need to confirm heroin involvement.
The test is done with a simple blood draw, usually from a vein in your arm. A healthcare professional will clean the site, wrap a band around your upper arm, and insert a small needle to collect the sample into a tube. The procedure takes only a few minutes and may cause brief, mild discomfort. You can typically return to your normal activities right afterward.
A healthcare professional will draw a blood sample from a vein in your arm using a needle. The blood is collected into a special tube and sent to a laboratory for analysis. The test looks for the presence or absence of 6-MAM in your blood, providing a qualitative result (positive or negative).
Your results show whether your blood cell levels fall within normal ranges. Low red blood cell or hemoglobin values may suggest anemia, while high or low white blood cell counts can point to infection, inflammation, or other conditions, and abnormal platelet levels may affect how your blood clots. Your provider will interpret the numbers together with your symptoms and medical history to decide whether further testing or treatment is needed.
A positive result means 6-MAM was detected in your blood, indicating recent heroin use within the past 24-48 hours. A negative result means no 6-MAM was detected, but this does not necessarily rule out heroin use entirely—it may mean the drug was used outside the detection window. Your healthcare provider will interpret the results in the context of your specific situation and medical history.
Reference range
Negative - No 6-MAM detected at the cutoff concentrationN/A
No special preparation required. Inform patient that this is a drug screen test. Collect sample according to chain of custody protocols if required for legal/forensic purposes.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
The 6-MAM test is clinically significant because it provides specific evidence of heroin use, unlike general opioid tests that may be positive from prescription pain medications. It is valuable in addiction medicine for monitoring patients in treatment programs, in pain management to differentiate illicit drug use from prescribed opioid use, and in forensic settings for legal or investigation purposes. The relatively short detection window (24-48 hours in blood) makes it useful for determining recent use rather than past use.
Frequently asked questions
How long does heroin stay detectable in blood?
Will this test show if I use other pain medications?
Is the test confidential?
Do I need to prepare for the test?
Sources
- 1
- 2
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy