Skip to content

Alpha-1 Antitrypsin, 24-Hour Stool — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures alpha-1 antitrypsin in stool collected over 24 hours to help evaluate gastrointestinal loss of this protein.

Quick summary

["This test can help identify whether alpha-1 antitrypsin is being lost through the digestive tract."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46429-7
Short code
A1AT 24h Stl-mCnt
Synonyms
A1AT 24h Stl-mCnt
Category
liver
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of alpha-1 antitrypsin, a protein made by the liver, in a 24-hour stool collection. It is mainly used to evaluate whether protein is being lost through the digestive tract.

Why might I need this test?

Your clinician may order this test if you have unexplained swelling, low blood protein, or symptoms that suggest a gastrointestinal disorder. It may help assess for protein-losing enteropathy, a condition in which the intestine loses too much protein.

How is the test performed?

You collect all stool produced during a full 24-hour period and submit the container to the laboratory as instructed. The laboratory measures alpha-1 antitrypsin in the collected specimen.

How do I prepare for the test?

Follow the collection instructions provided by your clinician or laboratory, including the exact start and stop times. Do not start a 24-hour collection until you have the proper container and clear instructions, and tell the laboratory about any medicines or supplements you use.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Stool Alpha-1 Antitrypsin

Frequently asked questions

What is alpha-1 antitrypsin?
Alpha-1 antitrypsin is a protein made by the liver that travels through the blood and helps control inflammation. It can also be lost into the digestive tract.
Why is a 24-hour stool collection needed?
A 24-hour collection accounts for all stool produced during a complete day. This helps the laboratory measure the total amount of alpha-1 antitrypsin more reliably than a single sample.
Does an abnormal result diagnose a specific condition?
No. An abnormal result may support protein loss through the intestines but does not identify the exact cause by itself. Your clinician will interpret it alongside your medical history, examination, and other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy