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Alpha-1 Antitrypsin, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of alpha-1 antitrypsin in blood to help evaluate low protein levels and possible alpha-1 antitrypsin deficiency.

Quick summary

["This blood test can help determine whether low alpha-1 antitrypsin levels contribute to lung or liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1826-7
Short code
A1AT MM SerPl-mCnc
Synonyms
A1AT MM SerPl-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Alpha-1 antitrypsin is a protein made by the liver that helps protect the lungs from inflammation. This test measures its concentration in serum or plasma, the liquid portion of blood.

Why might I need this test?

Your doctor may order this test if you have unexplained chronic lung disease, repeated lung infections, or liver disease. It may also be used when family members have a history of alpha-1 antitrypsin deficiency.

How is the test performed?

A blood sample is drawn from a vein and analyzed in the laboratory to determine the concentration of alpha-1 antitrypsin. The laboratory method may vary, so the test report should be reviewed with your healthcare professional.

How do I prepare for the test?

No special preparation is usually needed. Tell your doctor if you are pregnant, have an acute infection, or recently received intravenous human immunoglobulin, because these factors can affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 Antitrypsin

Frequently asked questions

Does a low alpha-1 antitrypsin result mean I have a lung disease?
No. A low result can suggest alpha-1 antitrypsin deficiency, but it does not diagnose a specific lung condition by itself. Your doctor will interpret the result along with your symptoms, examination, and other tests.
Can this test be done during an infection or while I am pregnant?
The test can usually be performed at any time, but acute infection, inflammation, pregnancy, and some treatments may affect the measured level. Your doctor can determine whether repeat or confirmatory testing is appropriate.
Is genetic testing needed if my alpha-1 antitrypsin level is low?
Sometimes. If a low level suggests an inherited deficiency, your doctor may recommend genetic or protein testing to identify the specific variant and help assess risk for you and your family.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy