Skip to content

Alpha-1 Antitrypsin, Stool — Quantitative Mass Measurement

Published: August 9, 2026Updated: August 16, 2026

A stool test that measures alpha-1 antitrypsin, which can help assess pancreatic function and intestinal inflammation.

Quick summary

["This test uses a stool sample to help evaluate pancreatic function and may support investigation of intestinal inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
111064-2
Short code
A1AT Msmt Stl
Synonyms
A1AT Msmt Stl
Category
liver
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

What is this test?

The fecal alpha-1 antitrypsin test measures the amount of alpha-1 antitrypsin in stool. This protein is produced by the pancreas and is relatively resistant to breakdown in the digestive tract.

Why might I need this test?

This test may be used to help evaluate reduced pancreatic function, particularly when symptoms suggest the pancreas is not producing enough digestive enzymes. It may also be considered during evaluation of persistent diarrhea or suspected intestinal inflammation.

How is the test performed?

A stool sample is collected and the laboratory measures its alpha-1 antitrypsin content. The result is compared with the laboratory's reference range and interpreted along with symptoms, medical history, and other tests.

How do I prepare for the test?

Special preparation is often unnecessary, but follow the laboratory's collection instructions. During collection, avoid contaminating the sample with urine or toilet paper, and tell the care team if you have taken antibiotics or other medicines that could affect digestion.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Fecal alpha-1 antitrypsin test

Frequently asked questions

What does the fecal alpha-1 antitrypsin test measure?
It measures the amount of alpha-1 antitrypsin in stool. The protein comes mainly from the pancreas and passes through the digestive tract largely intact.
Why is a stool sample used?
Alpha-1 antitrypsin is relatively stable during digestion, so its amount in stool can reflect pancreatic enzyme activity. This makes it useful as an indirect marker of pancreatic function.
Does an abnormal result confirm a specific condition?
No. Abnormal results may occur with several digestive conditions and must be interpreted with symptoms and other pancreatic or gastrointestinal tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy