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Alpha-1 Antitrypsin, Serum/Plasma — Electrophoresis, Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This blood test measures the amount of alpha-1 antitrypsin, a protein that helps protect the lungs and liver from damage.

Quick summary

["The result can help identify alpha-1 antitrypsin deficiency, an inherited condition that may increase the risk of lung and liver disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
98994-7
Short code
A1AT SerPl Elph-mCnc
Synonyms
A1AT SerPl Elph-mCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
electrophoresis
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures the concentration of alpha-1 antitrypsin in your blood. This protective protein is made mainly by the liver and helps prevent damage to lung tissue.

Why might I need this test?

Your doctor may order this test if you have unexplained liver disease, chronic lung disease, or a family history of alpha-1 antitrypsin deficiency. It may also be used to monitor someone with a known low alpha-1 antitrypsin level.

How is the test performed?

A blood sample is collected and analyzed using electrophoresis, which separates proteins so alpha-1 antitrypsin can be identified and measured. The sample may be tested as serum or plasma, depending on the laboratory.

How do I prepare for the test?

This test usually requires no special preparation. Follow your doctor's instructions and tell the laboratory if you are pregnant or have recently received a blood or plasma transfusion, because these factors may affect the results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Alpha-1 antitrypsin test

Frequently asked questions

What does alpha-1 antitrypsin do?
Alpha-1 antitrypsin is a protein that protects the lungs from inflammation and injury. It also helps limit damage to the liver.
Is alpha-1 antitrypsin deficiency inherited?
It is usually inherited through changes in a gene called SERPINA1. A doctor or genetic counselor can explain inheritance patterns and whether family testing may be appropriate.
Does this test diagnose a specific lung or liver condition?
No. The result can identify low alpha-1 antitrypsin levels and may support evaluation for a deficiency, but your doctor must interpret it alongside your clinical findings and other tests.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy