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Alpha-1-Microglobulin, 24-Hour Urine — Mass Rate

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of alpha-1-microglobulin excreted in urine over 24 hours. This protein test can help assess kidney filtering and reabsorption function.

Quick summary

["An increased amount in 24-hour urine may indicate impaired kidney tubule function or increased protein loss."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48414-7
Short code
A1 Microglob 24h Ur-mRate
Synonyms
A1 Microglob 24h Ur-mRate
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures alpha-1-microglobulin, a small blood protein that passes through the kidneys' filters and is normally reabsorbed by the kidney tubules. It is measured in urine collected for 24 hours and reported as the amount excreted over that period.

Why might I need this test?

A clinician may order this test to evaluate kidney function, particularly when protein is found in the urine or when conditions that may affect the kidney tubules are being monitored.

How is the test performed?

You collect all urine for a full 24-hour period, following the laboratory's collection instructions. The total amount of alpha-1-microglobulin in the collection is then measured and reported as a rate.

How do I prepare for the test?

Begin and finish the collection at the times specified by the laboratory, usually 24 hours apart, and include every urine sample during that period. Record the start and end times, keep the container tightly closed, and refrigerate or handle it as instructed until delivery.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Alpha-1-Microglobulin

Frequently asked questions

Why is a 24-hour urine collection needed?
A one-time urine sample can vary with fluid intake and the time of day. Collecting all urine for 24 hours provides a more complete measure of how much of the protein is being excreted.
What can cause an elevated result?
Elevated urinary alpha-1-microglobulin may occur when kidney tubules are not functioning normally or when there is increased protein loss. Your clinician will interpret it alongside other kidney and urine tests.
What if some urine is missed during the collection?
A missed sample can make the result inaccurate, often causing the measured amount to appear lower. Tell the laboratory if collection was incomplete and ask whether the test should be repeated.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy