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Alpha-1-Microglobulin and Creatinine, 24-Hour Urine

Published: August 9, 2026Updated: August 16, 2026

Measures alpha-1-microglobulin and creatinine in a 24-hour urine collection to help evaluate how well the kidneys filter and reabsorb small proteins.

Quick summary

["This test can help detect impaired reabsorption of small proteins by the kidney tubules."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99075-4
Short code
A1 Microglob/Creat 24h Ur
Synonyms
A1 Microglob/Creat 24h Ur
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Alpha-1-microglobulin is a small protein that is filtered by the kidneys and normally reabsorbed by the kidney tubules. This test measures alpha-1-microglobulin and creatinine in urine collected for 24 hours; creatinine helps account for differences in urine concentration.

Why might I need this test?

A clinician may order this test to assess kidney tubular function, especially if there is concern about kidney damage, inflammation, or medication effects. It may also be used alongside other urine and blood tests when monitoring people at risk for kidney disease.

How is the test performed?

You collect all urine produced during a full 24-hour period in a labeled container provided by the laboratory. The laboratory then measures the amount of alpha-1-microglobulin and creatinine in the collection.

How do I prepare for the test?

Follow the laboratory’s collection instructions carefully, including the start and end times and how to store the container. A missed collection or urine spilled from the container can make the results inaccurate; ask the laboratory whether any medications or other tests could affect the collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Alpha-1-Microglobulin and Creatinine

Frequently asked questions

Does this test require fasting?
Fasting is generally not required for a 24-hour urine collection, but follow the specific instructions provided by the laboratory or your clinician.
What can cause an abnormal result?
Elevated urinary alpha-1-microglobulin can occur with impaired kidney tubular reabsorption, including some kidney diseases and certain medication effects. An incomplete collection or very concentrated or dilute urine can also affect interpretation.
How is a 24-hour urine collection done?
Usually, you empty your bladder at the start time, then collect every urine sample for the next 24 hours in the supplied container. At the end of the period, you collect the final sample and return the container to the laboratory as instructed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy