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Alpha-1 Microglobulin, Urine — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of alpha-1 microglobulin in urine. This protein helps assess kidney filtering and tubular reabsorption function.

Quick summary

["An elevated urine level may indicate impaired function of the kidney's small filtering tubules."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46723-3
Short code
A1 Microglob Ur-mCnc
Synonyms
A1 Microglob Ur-mCnc
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures alpha-1 microglobulin, a small protein normally present in urine. It is filtered by the kidneys and then reabsorbed by the kidney tubules, so the result can help evaluate how well these structures are working.

Why might I need this test?

Your clinician may order this test to investigate kidney damage, especially problems affecting the proximal tubules that reabsorb filtered substances. It may be used alongside urine protein, creatinine, albumin, and kidney function tests.

How is the test performed?

A urine sample is collected and tested in a laboratory to determine the concentration of alpha-1 microglobulin. The result may be reported alone or compared with urine creatinine to account for differences in urine concentration.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. A first-morning or clean-catch urine sample may be requested, and you may be advised to avoid vigorous exercise and collection during an illness or fever.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine alpha-1 microglobulin

Frequently asked questions

What does alpha-1 microglobulin measure?
It measures the amount of a small protein in urine that is normally filtered and then reabsorbed by the kidneys.
What does a high result mean?
A high result may suggest that the kidney tubules are not reabsorbing this protein as efficiently as expected. Other laboratory findings are needed to determine the cause.
Is this test the same as a urine protein test?
No. It measures a specific protein, while a general urine protein test measures several types of protein and may also include albumin.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy