Skip to content

Alpha-1 Antitrypsin, Urine — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the concentration of alpha-1 antitrypsin in urine. This result is interpreted with liver and kidney function and other clinical findings.

Quick summary

["This urine test measures alpha-1 antitrypsin and may help evaluate how the body produces and excretes this protective protein."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
1793-9
Short code
AAA Ur-mCnc
Synonyms
AAA Ur-mCnc
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

Alpha-1 antitrypsin is a protein made mainly by the liver that helps protect tissues from enzymes that can cause inflammation and damage. This test measures the amount of this protein concentrated in a urine sample.

Why might I need this test?

A urinary alpha-1 antitrypsin measurement may be used as part of an evaluation involving liver disease, inherited alpha-1 antitrypsin deficiency, or kidney function. It is usually interpreted together with blood tests and other clinical information.

How is the test performed?

A urine specimen is collected and analyzed in the laboratory to determine the mass concentration of alpha-1 antitrypsin. Because urine concentration changes with fluid intake, results may be compared with urine creatinine or another measure of kidney function.

How do I prepare for the test?

Follow the laboratory's instructions for urine collection, including whether a first-morning or random sample is needed. Use the provided sterile container and tell the healthcare provider if you have a urinary tract infection, kidney disease, or are taking medicines that may affect the result.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urinary alpha-1 antitrypsin

Frequently asked questions

Is this the same as the alpha-1 antitrypsin blood test?
No. This test measures alpha-1 antitrypsin in urine, whereas the more common blood test measures its concentration in serum or plasma. The two results provide different information and may be reviewed together.
Does the amount of urine I produce affect the result?
Yes. Urine can become more or less concentrated depending on fluid intake, so the laboratory may compare this result with urine creatinine to help interpret it.
Does one abnormal result confirm alpha-1 antitrypsin deficiency?
No. A diagnosis of alpha-1 antitrypsin deficiency generally requires blood testing and, when appropriate, genetic testing. A urine result must be interpreted with the rest of your medical evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy