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Alpha-Aminoadipic Semialdehyde and Delta-1-Pyrroline-6-Carboxylate (AASA/P6C), Serum/Plasma — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

A specialized blood test measures two metabolites involved in lysine and connective-tissue metabolism.

Quick summary

["This test helps evaluate rare inherited disorders that affect how the body processes lysine-related metabolites."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92766-5
Short code
AASA+P6C SerPl-sCnc
Synonyms
AASA+P6C SerPl-sCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test measures alpha-aminoadipic semialdehyde (AASA) and delta-1-pyrroline-6-carboxylate (P6C) in serum or plasma. These compounds are part of the metabolic pathways involving lysine and connective-tissue formation.

Why might I need this test?

This specialized test may be ordered when symptoms suggest a rare inherited metabolic disorder, particularly an abnormality in the breakdown of lysine-related metabolites. It is usually interpreted by a metabolic specialist alongside other laboratory and genetic tests.

How is the test performed?

A blood sample is collected, and either serum or plasma is separated from it. A laboratory then uses a validated analytical method to measure the AASA and P6C concentrations.

How do I prepare for the test?

Special preparation is generally not required unless the ordering laboratory gives specific instructions. Follow the laboratory's directions regarding fasting, medication use, and sample collection, and do not stop prescribed medicines unless your clinician advises you to do so.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

AASA/P6C, Serum/Plasma

Frequently asked questions

What does the AASA/P6C test measure?
It measures the concentrations of two metabolites called alpha-aminoadipic semialdehyde (AASA) and delta-1-pyrroline-6-carboxylate (P6C) in serum or plasma.
Why is this test ordered?
It may be used to evaluate suspected rare inherited disorders involving lysine or connective-tissue metabolism. The test is often part of a broader metabolic evaluation.
Does an abnormal result mean I have a genetic disorder?
Not necessarily. The result must be interpreted by a qualified clinician in the context of your symptoms, other tests, and possible confirmatory testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy