Blood Test Overview: What This Lab Test Means for Your Health
This blood test measures amino acids involved in the urea cycle to help diagnose disorders that affect how your body removes ammonia.
{"Measures amino acids (arginine, citrulline, ornithine) in blood","Helps diagnose urea cycle disorders that cause ammonia buildup","Performed using advanced mass spectrometry technology","Requires fasting overnight before blood draw","Results help guide treatment for metabolic disorders"}
Key facts at a glance
- LOINC
- 100368-0
- Short code
- AA Urea Cycle Panel
- Synonyms
- AAUCD SerPl LC/MS/MS
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube; plasma (EDTA or heparin) acceptable
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- lc-ms-ms
- CPT
- 82131
- SNOMED
- 313335009
- Specimen volume
- 1-2 mL serum or plasma minimum
- Stability
- Room temperature: 24 hours; Refrigerated (2-8°C): 72 hours; Frozen (-20°C or below): 2 weeks to 30 days
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 72–168 hours
- Order
- routine
This is a laboratory test that measures specific substances in a sample of your blood to help your healthcare provider evaluate your overall health, screen for certain conditions, or monitor a treatment plan you may already be following.
The Amino Acids Urea Cycle Panel is a blood test that measures the levels of specific amino acids involved in the urea cycle. The urea cycle is a process in your liver that converts harmful ammonia into urea, which is then excreted in urine. This test uses a sophisticated laboratory method called liquid chromatography-tandem mass spectrometry (LC/MS/MS) to accurately measure amino acid levels in your blood.
Your provider may recommend this test to check how well your organs are working, look for early signs of disease, confirm or rule out a suspected diagnosis, or track whether your current medications and lifestyle changes are effective over time.
Your doctor may order this test if you have symptoms of a urea cycle disorder, such as unusual sleepiness, vomiting, confusion, or developmental delays, especially in infants and children. It may also be used to monitor patients already diagnosed with urea cycle disorders or to evaluate family members of affected individuals.
In most cases you can eat and drink normally unless your provider asks you to fast for a certain number of hours beforehand. Drink plenty of water, wear a shirt with sleeves that roll up easily, and tell your care team about all medicines, vitamins, or supplements you take.
You will typically need to fast (not eat or drink anything except water) for 8-12 hours before the blood draw. Your doctor will provide specific instructions. Certain medications may affect test results, so inform your healthcare provider about all medications and supplements you are taking.
A trained technician will wrap a band around your upper arm, clean the skin at the draw site, and insert a small needle into a vein, usually in your arm. A small amount of blood is collected into a tube, the needle is removed, and a bandage is applied to the spot.
A healthcare professional will draw a small blood sample from a vein in your arm. The blood will be collected in a tube and sent to a laboratory for analysis using LC/MS/MS technology. The test typically takes a few days to complete as special equipment is required.
This test is very safe. You may feel a quick sting when the needle goes in, and mild bruising or soreness at the site is common. Serious problems such as infection or excessive bleeding are rare. Tell your provider if you bleed easily or take blood thinners.
The risks are minimal and include slight pain or bruising at the injection site, dizziness, or very rarely, infection. These blood draw risks are generally minor and resolve quickly.
Reference range
Reference ranges are specific to each amino acid measured in the panel. Results are interpreted based on age-specific reference intervals for individual amino acids including arginine, citrulline, ornithine, carbamoyl phosphate, and related metabolites.N/A
No special preparation required. Fasting is not mandatory but may be requested for certain clinical indications. Collect specimen according to standard venipuncture protocol.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
What do abnormal results mean?
How long does it take to get results?
Do I need to stop taking my medications?
Can this test be done on children?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy