Urine Protein-to-Creatinine Ratio (24-hour collection)

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or changes in how much you urinate. It’s also used to check for conditions like kidney disease, diabetes, or high blood pressure that can affect kidney function. Sometimes, it’s part of a routine checkup for people at higher risk of kidney problems.

How the Test Works

You’ll collect all your urine for a full 24-hour period, typically starting and ending at the same time each day. The sample is then tested in a lab to compare protein levels to creatinine, a waste product your kidneys normally filter out.

What to Expect Before the Test

No special preparation is needed, but you should drink enough fluids to produce urine consistently throughout the day. Avoid taking certain medications (like some blood pressure drugs) without talking to your doctor first, as they can affect results.

What to Expect During the Test

You’ll collect your urine in a container for the full 24 hours, changing the container every time you urinate. A healthcare provider may give you instructions on how to start and stop the collection period correctly.