About This Test: What Patients Need to Know
This test checks for the presence of both acetaminophen (a pain reliever) and oxycodone (a strong pain medication) in your blood.
{"The test detects two pain medications: acetaminophen (Tylenol) and oxycodone (a prescription opioid)","It helps doctors monitor medication levels and ensure safe dosing","Blood is drawn from a vein in your arm for this test","Results help healthcare providers check for overdose or verify proper medication use"}
Key facts at a glance
- LOINC
- 43719-4
- Short code
- ACET-OXY
- Synonyms
- Acetamin+oxyCODONE SerPl Ql
- Category
- chemistry
- Sample
- serum
- Container
- Serum Separator Tube (SST) or Plain Red Top Tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 18 years
- Method
- Immunoassay (Chemiluminescent Microparticle Chemiflex)
- CPT
- 80307
- SNOMED
- 122461009
- Specimen volume
- 1.0 mL minimum, 2.0 mL preferred
- Stability
- Room temperature: 24 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days
- Hemolysis max
- 50
- Lipemia max
- 50
- Icterus max
- 20
- TAT
- 4–24 hours
- Order
- routine
This test is a diagnostic procedure that helps your healthcare provider gather important information about your health. It involves examining a sample, such as blood, urine, or tissue, or using imaging technology to evaluate how your body is functioning and to support an accurate diagnosis and treatment plan.
The Acetaminophen and Oxycodone blood test is a laboratory test that detects whether both medications are present in your bloodstream. Acetaminophen is found in over-the-counter pain relievers like Tylenol, while oxycodone is a prescription opioid medication used for moderate to severe pain management. This test can determine if these drugs are in your system and in some cases, measure how much is present.
Your doctor may order this test to confirm or rule out a suspected condition, monitor an ongoing illness, or check how well your current treatment is working. It can also be part of a routine checkup to screen for potential health problems before symptoms appear, allowing earlier care when needed.
Your healthcare provider may order this test for several reasons: to monitor your medication levels if you are taking both drugs, to check for accidental or intentional overdose, to ensure you are taking your medications as prescribed, or to evaluate symptoms of drug toxicity such as nausea, dizziness, or liver problems.
The test is usually performed by a trained healthcare professional in a clinic, hospital, or laboratory. Depending on the type of test, a small sample of blood may be drawn from a vein in your arm, or you may be asked to provide a urine or other sample. The procedure is typically quick, and most people can return to their normal activities right afterward.
A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood sample will be sent to a laboratory for analysis. The test requires a serum or plasma sample, which is obtained after the blood is processed in the lab. You do not need to fast before this test unless your doctor specifically instructs you to do so.
Your results will show whether the measured values fall within the normal reference range for this test. Results within the expected range usually suggest no apparent abnormality, while values that are higher or lower than normal may indicate a condition that requires further evaluation. Your healthcare provider will review the findings with you and explain what they mean for your health.
Results are typically reported as 'detected' or 'not detected,' or may show the specific concentration of each medication in your blood. Your doctor will interpret these results based on your medical history, the medications you are currently taking, and your symptoms. Having these medications in your system may be expected if you are under treatment, but unexpectedly high levels could indicate an overdose.
Reference range
Not Detected - This is a qualitative test for the presence of acetaminophen and oxycodone. Results are reported as Detected or Not Detected.N/A
No fasting required. Inform laboratory of all medications including over-the-counter pain relievers, prescription opioids, and supplements. Recent ingestion of acetaminophen-containing products should be disclosed.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
How long do these drugs stay in your blood?
Will this test show if I'm taking too much medication?
Do I need to stop taking my medications before the test?
Is the test painful?
Sources
- 1
- 2
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy