Acetazolamidebldmcnc
This test measures the amount of acetazolamide, a carbonic anhydrase inhibitor medication, in your blood to ensure proper dosing and therapeutic effectiveness.
{"Measures acetazolamide concentration in whole blood samples","Helps doctors monitor drug levels for safety and effectiveness","Used to treat glaucoma, altitude sickness, epilepsy, and fluid retention","Ensures drug levels are within therapeutic range","May help adjust dosage to prevent side effects or toxicity"}
Key facts at a glance
- LOINC
- 59598-3
- Short code
- ACET
- Synonyms
- acetaZOLAMIDE Bld-mCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender top (EDTA) tube or green top (heparin) tube for whole blood collection
- Units
- N/A
- Ref low
- 5
- Ref high
- 15
- Critical range
- — – 40 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- High Performance Liquid Chromatography (HPLC) with UV detection or Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
- CPT
- 80307
- SNOMED
- 385058006
- Specimen volume
- 2-3 mL of whole blood
- Stability
- Room temperature (20-25°C): 7 days; Refrigerated (2-8°C): 14 days; Frozen (-20°C or below): 30 days. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The Acetazolamide Blood Level Test is a laboratory test that measures the concentration of acetazolamide in your blood. Acetazolamide is a prescription medication called a carbonic anhydrase inhibitor. This test helps your healthcare provider determine if the amount of medication in your blood is at the right level to be effective for your condition.
Why is this test performed?
This test is performed for several important reasons: (1) To monitor that acetazolamide levels are within the therapeutic range - not too low (which would make the medication ineffective) and not too high (which could cause side effects). (2) To help your doctor adjust your dosage to achieve the best treatment results. (3) To ensure patient safety by detecting potentially dangerous levels of the medication.
What conditions does acetazolamide treat?
Acetazolamide is prescribed to treat various conditions including: open-angle glaucoma (to reduce eye pressure), altitude sickness (to help your body adjust to high altitudes), certain types of epilepsy (as an anticonvulsant), and fluid retention (edema) associated with heart failure or certain medications. By measuring drug levels, doctors can ensure patients receive the optimal dose for their specific condition.
How is the test performed?
A healthcare professional will collect a blood sample from a vein in your arm using a small needle. The sample is then sent to a laboratory for analysis. The test requires a whole blood sample. Your doctor will tell you when to have this test done - often it is timed to occur just before your next dose (trough level) or at a specific time after taking your medication, depending on what information your doctor needs.
What do the results mean?
Results show the concentration of acetazolamide in your blood, measured in mass per volume. Therapeutic drug monitoring helps ensure you are receiving an appropriate dose. If levels are too low, your doctor may increase your dose. If levels are too high, your doctor may reduce your dose or check for other issues. The specific therapeutic range depends on the condition being treated and individual patient factors.
Reference range
Therapeutic range: 5-15 mcg/mL (trough levels). Peak levels (2-4 hours post-dose): 10-40 mcg/mL. Reference range may vary by laboratory methodology and clinical indication.N/A
Record the exact time of last acetazolamide dose and sampling time. No fasting required. Inform laboratory of current dosing schedule for accurate interpretation. Continue medication unless otherwise instructed by prescribing physician.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Do I need to fast before this test?
How often will I need this test?
What are the side effects of acetazolamide?
Will my dose be changed based on this test?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy