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Achromatic Block Antibody Screening in Serum

Published: August 9, 2026Updated: August 17, 2026

This test measures antibodies that may interfere with certain lab tests by blocking color changes in reactions. It helps ensure accurate results for other tests performed on your blood.

Quick summary

["This screening helps prevent false results in other blood tests by detecting antibodies that can interfere with their performance."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
33278-3
Short code
AChR Block Ab Ser-sCnc
Synonyms
AChR Block Ab Ser-sCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
198
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82553
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test helps your healthcare provider find out whether certain substances, markers, or conditions are present in your body. It is commonly used to screen for health problems early, confirm a diagnosis, or monitor a condition you already have. Early detection can make treatment more effective and helps you and your care team make informed decisions about your health.

Your healthcare provider may order this test if you’re scheduled for a blood test that uses color-based chemical reactions. Certain antibodies can bind to these chemicals, altering the test results and potentially leading to incorrect diagnoses or treatments. This screening helps identify if such interference is possible.

During this test, a small sample is collected from your body and examined in a laboratory using specialized equipment. The lab looks for specific markers or changes that show how your body is functioning. Trained professionals analyze the sample and send the findings to your healthcare provider, who interprets the results in the context of your overall health and symptoms.

A small sample of your blood is drawn and tested using a method that detects whether antibodies are present that could block color changes in specific chemical reactions. If interference is found, further testing may be needed to confirm the results of other blood tests.

Your healthcare provider will give you specific instructions before the test. You may be asked to avoid eating or drinking for several hours, skip certain medications or supplements, or avoid vigorous exercise. Wear comfortable clothing and plan to arrive a little early to complete any paperwork. Tell your care team about all medications, allergies, and medical conditions you have, and ask questions if anything is unclear.

No special preparation is needed for this screening. You may have a blood draw at your doctor’s office or a lab. If you’re taking blood thinners or have a history of bleeding disorders, let your provider know before the test.

Most people can return to their normal activities right away after this test. You may have slight soreness, bruising, or discomfort at the collection site, which usually goes away within a day or two. Drinking water and resting as needed can help. Your sample will be sent to a laboratory for analysis, and your provider will contact you with the results, typically within a few days. Call your provider if you notice unusual pain, swelling, or bleeding.

You’ll likely feel slight discomfort from the needle, but most people recover quickly. If you experience excessive bruising, swelling, or pain, contact your provider. Results are usually reported within a few days and will guide further testing if needed.

Reference range

Adult males: 22-198 U/L; Females: 22-198 U/LN/A

Specimen: serum

No special preparation required. Inform provider of any chest pain or symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Achromatic Block Antibody Screen

Frequently asked questions

This screening is primarily used to rule out antibody interference before other blood tests. If antibodies are detected, your provider may repeat the affected test using a different method or adjust the test protocol to avoid false results. It’s especially important for patients undergoing complex diagnostic testing or those with autoimmune conditions.
A positive result usually means the test detected the substance, marker, or condition it was designed to find. It does not always mean you are seriously ill, and some positive results require follow-up testing to confirm the finding. Your healthcare provider will explain what your specific result means, discuss possible next steps, and answer any questions you have about treatment or further evaluation.
A positive result means antibodies were found that could interfere with color-based chemical reactions in other tests. This does not indicate a specific medical condition but may require additional testing to ensure accurate results for other bloodwork.
How often you need this test depends on your age, overall health, risk factors, and the reason it was first ordered. Some people need it once a year, while others may need it more or less often. Your healthcare provider will recommend a testing schedule tailored to you, so it is important to follow their guidance and keep all of your scheduled appointments.
This screening is typically done only when needed, usually before specific blood tests that rely on colorimetric methods. Your provider will determine if repeat testing is necessary based on your clinical situation.
No fasting is required for this test. It’s a simple blood draw and doesn’t affect the accuracy of the screening.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy