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Cortolone–Pregnenolone Index, 24-Hour Urine — Mass Rate

Published: August 9, 2026Updated: August 16, 2026

This test measures a cortolone-related steroid pattern in urine collected for 24 hours. It may help assess adrenal steroid production when clinically indicated.

Quick summary

["The result reflects adrenal steroid activity and should be interpreted with other hormone tests and your symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57630-6
Short code
A-cortolone pre hi Dex 24h Ur-mRate
Synonyms
A-cortolone pre hi Dex 24h Ur-mRate
Category
liver
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This is a specialized urine test for a cortolone–pregnenolone steroid index. Cortolone and pregnenolone are related to adrenal hormone production, and the result is reported as a mass rate based on a 24-hour urine collection.

Why might I need this test?

A clinician may order this test when symptoms or other laboratory results suggest an adrenal steroid disorder. It is generally used as part of a broader evaluation rather than as a stand-alone diagnosis.

How is the test performed?

You collect all urine into a labeled container for a full 24-hour period. The laboratory then measures the steroid pattern and accounts for the amount and duration of the collection.

How do I prepare for the test?

Follow the laboratory's collection instructions exactly, including the start and end times. If instructed, refrigerate the container during collection and bring it to the laboratory when the collection is complete.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results may reflect increased or decreased adrenal steroid production or altered steroid metabolism. They can occur with adrenal disorders and may also be affected by medications or incomplete urine collection, so results should be interpreted by your clinician alongside symptoms and other tests.

Short name

24-hour urine cortolone–pregnenolone index

Frequently asked questions

Do I need to collect all of my urine for 24 hours?
Yes. This test requires a complete 24-hour collection, and missed urine can make the result inaccurate.
Can medications affect the result?
Yes. Steroid and other medications may alter adrenal hormone measurements. Tell your clinician about all medicines and supplements before the collection.
Does an abnormal result confirm an adrenal disorder?
No. This test is interpreted with your medical history, symptoms, and other laboratory findings because an abnormal result can have several causes.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy