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Alpha-1 Antitrypsin (Serum) Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin levels help identify potential lung or liver issues linked to genetic deficiencies."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
13193-8
Short code
A flavus Ab CSF-aCnc
Synonyms
A flavus Ab CSF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Matters

Alpha-1 Antitrypsin is crucial for maintaining lung and liver health. Low levels can increase the risk of chronic lung diseases like emphysema or liver cirrhosis, particularly if you have a family history of genetic disorders affecting this protein.

What to Expect Before the Test

No special preparation is needed. You may have a blood draw from a vein in your arm, similar to other blood tests. If you’re nervous, let your healthcare provider know so they can help you feel more comfortable.

What the Results Mean

Results are compared to a general reference range for healthy adults. Very low levels may suggest a genetic condition called Alpha-1 Antitrypsin Deficiency, which can cause lung or liver problems over time.

Common Reasons for Testing

Your doctor might order this test if you have symptoms like persistent coughing, shortness of breath, or unexplained liver issues. It’s also used in screening for families with a history of Alpha-1 Antitrypsin Deficiency.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin (Serum)

Frequently asked questions

What are the normal reference ranges for this test?
There is no single universal reference range for Alpha-1 Antitrypsin levels, as they can vary slightly between labs. Your healthcare provider will interpret your results in the context of your symptoms, medical history, and other test results. Very low levels may indicate a genetic disorder that requires further evaluation.
Can I eat or drink before this test?
You can eat and drink normally before this test, as no special preparation is required. However, avoid smoking or drinking alcohol for at least 24 hours before your blood draw to ensure accurate results.
Will this test hurt?
The blood draw itself may cause a slight pinch or discomfort, but it usually lasts only a few seconds. Most people feel little to no pain afterward. If you experience excessive bruising or pain, contact your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy