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Alpha-Fetoprotein, Serum/Plasma — Adjusted Multiples of the Median (MoM)

Published: August 9, 2026Updated: August 16, 2026

A blood test used during pregnancy that measures alpha-fetoprotein and adjusts the result for factors such as gestational age.

Quick summary

["Adjusted AFP is a prenatal screening marker, but an abnormal result alone does not diagnose a pregnancy complication."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
23811-3
Short code
AFP adj MoM SerPl
Synonyms
AFP adj MoM SerPl
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
10
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82105
SNOMED
394971007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Alpha-fetoprotein (AFP) is a protein that can be measured in blood. During pregnancy, the result may be adjusted for factors such as gestational age and reported as multiples of the median (MoM), which compares your result with typical results at the same stage of pregnancy.

Why might I need this test?

This test is commonly used as part of prenatal screening for open neural tube defects and certain chromosomal conditions, including Down syndrome. It is usually interpreted along with ultrasound findings and other screening tests.

How is the test performed?

A blood sample is taken from a vein and tested in a laboratory. The laboratory measures AFP and may convert the result to an adjusted MoM value for the relevant stage of pregnancy.

How do I prepare for the test?

No special preparation is usually required for the blood draw. Follow the testing center's instructions regarding timing, particularly if the test is part of routine prenatal screening.

Reference range

Normal: <10 ng/mLN/A

Specimen: serum

No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Adjusted AFP (MoM)

Frequently asked questions

Does an abnormal adjusted AFP result mean my baby has a condition?
No. An abnormal AFP result is a screening finding, not a diagnosis. Your clinician will consider it together with gestational age, ultrasound results, and other prenatal tests.
What does MoM mean?
MoM means multiples of the median. It shows how your AFP result compares with the typical result for people at the same stage of pregnancy.
Is this the same as a routine AFP test for liver disease?
The laboratory method may be similar, but an adjusted MoM result is generally intended for interpretation during pregnancy. Your clinician will explain which purpose applies to your result.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy