血细胞CD58(白细胞共同抗原相关蛋白)检测
本检测用于测量CD58的存在情况。CD58是一种存在于某些白细胞表面的蛋白,在免疫功能和细胞黏附过程中发挥作用。
["CD58有助于调节免疫反应和细胞间相互作用;在某些血液疾病或免疫功能评估中,可能会检测其水平。"]
关键信息一览
- LOINC
- 17176-9
- 简码
- CD58
- 别名
- CD58 Cells NFr Bld
- 类别
- 生化
- 样本
- whole-blood
- 采血管
- EDTA (purple-top) anticoagulant tube; ACD (yellow-top) tube is also acceptable for flow cytometry immunophenotyping. Heparinized tubes may be used but are not preferred for lymphocyte subset analysis.
- 单位
- N/A
- 参考下限
- 95
- 参考上限
- 100
- 是否空腹
- 否
- 适用人群
- 成人
- 性别
- all
- 年龄范围
- 0–120 岁
- 检测方法
- Flow cytometry (immunofluorescence) using fluorescently labeled monoclonal antibodies directed against CD58 (LFA-3) surface antigen, analyzed on whole blood leukocyte populations.
- CPT
- 88184 (Flow cytometry, cell surface, cytoplasmic, or nuclear marker, technical component only; first marker); additional markers billed with 88185.
- SNOMED
- 395126002 | Leukocyte surface marker finding (finding) |; CD58 antigen = 117449002
- 标本量
- 3-5 mL of whole blood for adults; 1-2 mL for pediatric patients collected in microtainer tubes.
- 标本稳定性
- Specimen should be processed within 24-48 hours of collection when stored at room temperature (18-25°C). Do not refrigerate or freeze whole blood specimens intended for flow cytometry, as this may cause cell clumping and loss of surface antigen expression. If processing is delayed beyond 48 hours, viability and antigen expression may be compromised.
- 溶血上限
- 0
- 脂血上限
- 0
- 黄疸上限
- 0
- 报告时间
- 24–72 小时
- 医嘱频率
- routine
可能需要做本检测的原因
如果您出现与免疫系统功能障碍相关的症状或疾病,例如慢性感染、自身免疫性疾病或某些血液疾病,您的医疗服务提供者可能会建议进行本检测。本检测也可能是评估影响白细胞功能的疾病或免疫检查点调节相关疾病的综合检查的一部分。
检测前需要做什么准备
通常不需要特殊准备。医生可能会从您手臂的静脉中抽取少量血液。如果您正在服用抗凝药物,请在检测前告知您的医疗服务提供者。
检测结果意味着什么
CD58水平可能因免疫活性、健康状况及其他因素而有所不同。结果异常可能提示免疫调节异常,但不能单独作为诊断依据。您的医疗服务提供者会结合您的病史和症状解读检测结果。
常见监测疾病
本检测不常用于常规筛查,但可能用于诊断重度联合免疫缺陷(SCID)、某些淋巴增殖性疾病或免疫检查点抑制剂相关不良反应等疾病。
Reference range
CD58 expression is normally present on most nucleated cells of hematopoietic origin including lymphocytes, monocytes, granulocytes, and erythroid precursors. Results are reported as percentage of CD58-positive cells within the gated leukocyte population and/or as absolute count per microliter. Reference ranges vary by laboratory and age; typical adult reference range is approximately 95-100% expression on lymphocytes and monocytes.N/A
No special patient preparation is required. Fasting is not necessary. Patients should be well-hydrated. Inform the laboratory of any recent immunosuppressive therapy, chemotherapy, or monoclonal antibody treatment, as these may alter lymphocyte subset distribution.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
简称
CD58水平
常见问题
哪些因素可能导致CD58水平异常?
本检测需要多久重复一次?
本检测需要空腹吗?
本信息仅供教育用途,不能替代专业医疗建议、诊断或治疗。
本内容仅供一般信息和教育用途,不能替代专业医疗建议、诊断或治疗。对于任何医疗问题,请务必咨询合格的医疗服务提供者;切勿因阅读本站内容而忽视专业医疗建议或推迟就医。
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医学审核:WellAlly 编辑团队 最后审核 2026年8月16日. · 阅读我们的编辑政策