Zuclopenthixol
Zuclopenthixol is a typical antipsychotic medication belonging to the thioxanthene class, primarily used to treat schizophrenia and other psychotic disorders. It is available in oral and long-acting injectable formulations, making it suitable for both acute management and maintenance therapy. This medication helps reduce symptoms such as hallucinations, delusions, and disorganized thinking.
Zuclopenthixol is an antipsychotic used to treat schizophrenia and related psychotic disorders by reducing dopamine activity in the brain.
Key facts at a glance
- ATC
- N05AF05
- RxNorm
- 114176
- Generic
- Zuclopenthixol
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of schizophrenia and other psychotic disorders, particularly for managing positive symptoms such as hallucinations, delusions, and thought disorders. It may also be used for severe anxiety and behavioral disturbances when other treatments have not been effective.
Zuclopenthixol works primarily by blocking dopamine D1 and D2 receptors in the brain, which helps reduce dopaminergic activity. It also has antagonist effects on alpha-adrenergic receptors and serotonin (5-HT2) receptors, contributing to its antipsychotic and calming effects.
Common side effects include extrapyramidal symptoms (such as tremors, rigidity, and akathisia), sedation, and anticholinergic effects. It should be used with caution in patients with cardiovascular disease, epilepsy, or Parkinson's disease. Regular monitoring for metabolic changes and cardiac function may be required during long-term treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy