Drug comparisons
Encainide vs Tocainide
Compare Encainide (class Ic antiarrhythmic, withdrawn after CAST trial) vs Tocainide (class Ib, withdrawn for agranulocytosis). Both oral, no longer available.
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Clinical context
This comparison typically arises when reviewing historical class I antiarrhythmics used for ventricular arrhythmias or investigating reasons older cardiac drugs were discontinued.
Bottom line
Neither Encainide nor Tocainide is available or recommended, as both were withdrawn after safety risks were found to outweigh any benefits.
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