Drug comparisons
Melatonin vs Ramelteon
OTC melatonin vs Rx ramelteon (Rozerem) for insomnia: both melatonin agonists. Key differences in FDA status, dosing precision, and clinical evidence for sleep onset.
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Clinical context
Patients considering switching from unregulated OTC melatonin to a prescription melatonin receptor agonist for persistent sleep-onset insomnia.
Bottom line
Ramelteon offers standardized prescription dosing as an approved agonist, while melatonin remains a widely available but variable OTC option; individual factors decide suitability.
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