Drug comparisons
Propoxyphene vs Salsalate
Propoxyphene vs Salsalate for pain: opioid vs NSAID. Propoxyphene withdrawn due to heart risks; Salsalate has NSAID black box warnings for CV and GI events.
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Clinical context
This comparison arises for patients with arthritis or musculoskeletal pain considering non-opioid alternatives after older analgesics like Propoxyphene.
Bottom line
Salsalate is a currently available NSAID option for certain inflammatory pains whereas Propoxyphene is no longer recommended due to safety withdrawal.
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