Drug comparisons
Sumatriptan vs Zavegepant
Compare Sumatriptan (Imitrex) vs Zavegepant (Zavzpret) for acute migraine: mechanisms, nasal/oral options, CV risks, and CGRP vs triptan differences.
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Clinical context
Patients with cardiovascular contraindications to triptans or inadequate response seeking a CGRP-targeted nasal alternative for acute migraine.
Bottom line
Zavegepant may suit those avoiding triptan vasoconstriction, while Sumatriptan remains a proven first-line option for many.
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