Drug comparisons
Tolbutamide vs Troglitazone
Tolbutamide stimulates insulin as a sulfonylurea; Troglitazone, a withdrawn TZD, improved sensitivity but caused hepatotoxicity. Both outdated for type 2 diabetes.
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Clinical context
Historical review of first-generation sulfonylurea versus withdrawn thiazolidinedione for type 2 diabetes patients.
Bottom line
Tolbutamide is still available as an older agent while Troglitazone was withdrawn for safety, so neither is first-line today.
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