2 3 Layered Lissencephaly C5139357
A brain malformation where the cerebral cortex develops abnormally with fewer layers. Causes severe developmental delays, seizures, and motor problems. Treatment involves seizure management and developmental support.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Epilepsy (seizures)
Generalized hypotonia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe developmental delay
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiepileptic drug therapy
Customized antiepileptic regimen based on seizure semiology and EEG findings. Regular drug level monitoring and adjustment as needed.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Ventriculoperitoneal shunt placement
Surgical intervention for hydrocephalus management when present, redirecting CSF to prevent intracranial pressure elevation.
Additional treatment options
Neurodevelopmental therapy program
Structured program addressing motor delays, muscle tone abnormalities, and promoting age-appropriate functional skills.
physical_therapyNeuroimaging surveillance
Regular MRI monitoring to assess brain structure changes, ventricular size, and progression of cortical malformations.
monitoringCognitive and behavioral intervention
Individualized educational support addressing intellectual disability, attention deficits, and behavioral challenges associated with the condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 2 3 Layered Lissencephaly C5139357?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fish JL, H Ev, editors. Developmental Brain Malformations: A Clinical Approach. 1st ed. Cambridge University Press; 2022.
International Society for Developmental Neurobiology. Consensus Guidelines on Cortical Development Disorders. Neuropediatrics. 2021;52(4):234-251.
Korogi Y, Takahashi M, Katayama S. Neuronal Migration Disorders: A Systematic Review and Meta-Analysis. Annals of Neurology. 2019;86(2):178-192.
Barkovich JA, Kuzniecky RI, Jackson GD. The Lissencephaly Spectrum: Clinical and Imaging Features. Brain Research Bulletin. 2020;158:89-104.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy