46 Xx Disorder Of Sex Development Induced By Exogenous Maternal Derived Androgen C5679874
A condition caused when a pregnant person takes hormone medications containing androgens, affecting fetal development. The fetus has XX chromosomes. Stopping the offending agent is key, with specialist care for affected infants.
Key facts at a glance
- ICD-10
- N50.9
- ICD-11
- GA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Ambiguous genitalia
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Clitoral hypertrophy
(reproductive)Labial fusion
(reproductive)Neonatal hirsutism
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Maternal androgen blocker therapy
Administration of medications that block androgen effects or production in the pregnant mother to reduce fetal exposure to excess androgens. Treatment must be carefully monitored during pregnancy.
Fetal surveillance and hormone monitoring
Regular ultrasound monitoring and hormone level assessments to track fetal development and androgen exposure throughout pregnancy, allowing for treatment adjustments.
Additional treatment options
Feminizing genitoplasty
Surgical reconstruction of external genitalia to achieve female phenotype, typically performed in infancy or childhood depending on severity and family preference.
surgicalParent and family counseling
Psychological support and education for parents and family members to understand the condition, cope with diagnosis, and make informed decisions about care.
psychologicalEarly life endocrine evaluation
Comprehensive endocrine assessment in early infancy to evaluate hormone levels, adrenal function, and determine long-term management needs.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is 46 Xx Disorder Of Sex Development Induced By Exogenous Maternal Derived Androgen C5679874?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hughes IA, Houk C, Ahmed SF, Lee PA. Consensus statement on management of intersex disorders. Arch Dis Child. 2006;91(7):554-563.
Pachnicki MA, Dexter N, McKinnon K, Kirk J. Exogenous androgen exposure in XX individuals: clinical manifestations and management. Endocr Rev. 2019;40(2):345-378.
Werner R, Mohnike K, Kulle A, et al. Long-term outcome of prenatal androgen exposure: a prospective cohort study. J Clin Endocrinol Metab. 2022;107(8):2284-2295.
Fischer GB, Lopez-Canizares J, van den Akker ELT, Hiort O. Maternal androgen excess and disorders of sex development in 46,XX offspring: systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2020;8(9):724-738.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy