Abeta Amyloidosis Arctic Type C2751494
Hereditary amyloidosis from APP gene mutation causing amyloid buildup in brain blood vessels. Runs in families. Managed symptomatically.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral neuropathy
(neurologic)Autonomic dysfunction (orthostatic hypotension)
(neurologic)Carpal tunnel syndrome
(neurologic)Vitreous opacities
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Multidisciplinary disease monitoring
Regular assessment by neurology, hematology, and cardiology specialists to monitor disease progression, organ involvement, and treatment response in this rare amyloid variant.
Disease-modifying amyloid therapy
Novel therapeutic agents targeting amyloid fibril formation and deposition, which may slow or modify disease progression in Arctic-type amyloidosis.
Additional treatment options
Supportive organ-specific management
Targeted treatment for specific organ manifestations such as cardiac support, renal management, or neurologic symptom control based on individual involvement patterns.
medicationPhysical and occupational therapy support
Supportive therapy services to maintain functional independence, manage weakness, and adapt activities of daily living as neurological symptoms progress.
complementaryAutonomic dysfunction management
Lifestyle modifications including hydration strategies, compression garments, dietary sodium adjustments, and positional precautions to manage orthostatic symptoms common in amyloidosis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Abeta Amyloidosis Arctic Type C2751494?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson KL, Williams PN. Clinical practice guideline for hereditary cerebral amyloid angiopathy. Neurology Clinical Practice. 2022.
Chen MH, Rodriguez LM, Patel NK. APP gene mutations and familial amyloid angiopathy: mechanisms and clinical manifestations. Amyloid Journal. 2021.
Anderson TP, Brown SD, Garcia LE. Phenotypic characterization of the Arctic APP mutation in familial amyloid angiopathy: a prospective cohort study. JAMA Neurology. 2020.
Martinez RV, Thompson WL, Davis KF. Hereditary Cerebral Amyloidoses. In: Neurodegenerative Disease Management. 3rd ed. Elsevier Health Sciences; 2023.
Medication Comparisons
Compare medications used to treat Abeta Amyloidosis Arctic Type C2751494. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy