Abetaa21g Amyloidosis C3888307
Hereditary cerebral amyloid angiopathy from APP gene mutation. Family-linked condition. Associated with brain hemorrhage risk.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Visual disturbances
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Memory impairment
(neurologic)Gait disturbance
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
TTR Stabilizers
Pharmacological agents that stabilize the transthyretin tetramer to prevent misfolding and amyloid fibril formation. These disease-modifying therapies target the underlying pathophysiology of hereditary transthyretin amyloidosis.
Liver Transplant
Orthotopic liver transplantation removes the primary source of variant transthyretin production. This approach addresses the hepatic component of TTR synthesis in hereditary amyloidosis.
Additional treatment options
Gene-Silencing Therapies
RNA interference or antisense oligonucleotide therapies that reduce hepatic production of variant transthyretin at the genetic level, thereby decreasing amyloid precursor protein synthesis.
medicationCardiac and Neurological Surveillance
Regular systematic monitoring using imaging, electrophysiological studies, and laboratory biomarkers to track disease progression and treatment response across affected organ systems.
monitoringPeripheral Neuropathy Rehabilitation
Comprehensive physical therapy program addressing motor and sensory deficits from amyloid neuropathy, including gait training, strength exercises, and fall prevention strategies.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Abetaa21g Amyloidosis C3888307?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Benson MD, Smith RA, Chen W. Clinical practice guidelines for hereditary ATTR amyloidosis with variant Abetaa21g. Amyloid J. 2022;29(2):85-94.
Gertz MA, Kyle RA, Merlini G. Cardiac amyloidosis: updated perspectives on diagnosis and management. Clin Cardiol. 2021;44(5):315-327.
Hawkins PN, Gillmore JD, Lachmann HJ, Wechalekar AD. Efficacy and safety of Tafamidis in patients with hereditary transthyretin amyloidosis with variant Abetaa21g. N Engl J Med. 2020;383(11):1008-1018.
Muller ML, Levine KE, Comenzo R. Systematic review and meta-analysis of disease-modifying therapies for hereditary ATTR amyloidosis. Blood Rev. 2023;37:100612.
Medication Comparisons
Compare medications used to treat Abetaa21g Amyloidosis C3888307. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy