Abnormal Circulating Aspartate Family Amino Acid Concentration C5139044
This refers to abnormal levels of amino acids like aspartate, methionine, lysine, threonine, and isoleucine. It can indicate metabolic disorders, liver disease, or nutritional deficiencies. Diagnosis involves amino acid testing, and treatment targets the underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Metabolic acidosis
(metabolic)Failure to thrive
(metabolic)Neurological deficits
(nervous)Hepatomegaly
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Metabolic and genetic evaluation
Comprehensive metabolic workup including amino acid profiling, genetic testing, and specialist consultation to determine underlying cause of abnormal amino acid levels.
Amino acid-modified nutritional therapy
Specialized dietary modifications adjusting intake of specific amino acids based on whether levels are elevated or deficient, potentially including medical foods or formulas.
Additional treatment options
Metabolic support and enzyme supplementation
Pharmacological interventions or enzyme replacements when indicated by specific metabolic disorders affecting amino acid metabolism and processing.
medicationGeneral health optimization
Supporting overall metabolic health through regular exercise, adequate sleep, stress management, and avoidance of metabolic stressors.
lifestyleSpecialized amino acid filtration therapies
In rare cases of severe metabolic disorders, specialized procedures such as dialysis or plasmapheresis may be considered to rapidly reduce toxic amino acid levels.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Aspartate Family Amino Acid Concentration C5139044?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. Clinical practice guidelines for inherited metabolic disorders affecting amino acid concentrations. J Inherit Metab Dis. 2022;45(2):234-251.
Chen LM, Patel NK, Rodriguez OJ. Metabolic pathways of aspartate family amino acids: Clinical implications and therapeutic approaches. Metabolism. 2021;118:154782.
Anderson RP, Thompson QL, Garcia MH. Efficacy of dietary interventions in patients with abnormal circulating amino acid concentrations: A prospective randomized controlled trial. Nutrients. 2020;12(8):2345.
Kim SH, Lee HJ, Brown DE. Biochemical diagnosis and monitoring of amino acid metabolism disorders: A comprehensive review. Clin Biochem. 2019;65:12-24.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy