Abnormal Circulating Deoxycorticosterone Level C4477025
Deoxycorticosterone is a steroid hormone that influences blood pressure and salt balance. Abnormal levels can lead to hypertension or electrolyte disturbances. Treatment typically involves medications to regulate blood pressure and hormone levels.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Irregular heartbeat
Heart rhythm disturbances caused by significant electrolyte imbalances, particularly low potassium.
Seek immediate medical attention if experiencing chest pain, severe dizziness, or palpitations with shortness of breath.
Severe muscle paralysis
Sudden onset of muscle paralysis or severe weakness due to dangerous potassium levels.
Seek emergency care immediately if experiencing sudden onset of paralysis or inability to move limbs.
Fatigue
(constitutional)Persistent tiredness and lack of energy that is not relieved by rest.
Frequency: 70-80% of patients
High blood pressure
(cardiovascular)Frequency: 65-75% of patients
Muscle weakness
(neurologic)Generalized weakness, particularly in the proximal muscles, often related to electrolyte imbalances.
Frequency: 40-50% of patients
Fluid retention
(cardiovascular)Swelling in the ankles, feet, or legs due to sodium and water retention.
Frequency: 35-45% of patients
Salt craving
(constitutional)Strong desire to eat salty foods due to mineralocorticoid imbalance.
Frequency: 30-40% of patients
Muscle cramps
(gastrointestinal)Painful, involuntary muscle contractions often related to low potassium levels.
Frequency: 15-25% of patients
Headache
(neurologic)Persistent or recurring headaches that may be related to blood pressure changes.
Frequency: 15-20% of patients
Frequent urination
(genitourinary)Increased urinary frequency, especially at night, due to electrolyte imbalances.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Glucocorticoid Replacement Therapy
Hydrocortisone or other glucocorticoid replacement addresses the underlying cortisol deficiency that contributes to elevated deoxycorticosterone levels.
Sodium-Restricted Diet
Reduced sodium intake helps manage hypertension associated with mineralocorticoid excess and supports overall cardiovascular health.
Additional treatment options
Blood Pressure and Hormone Monitoring
Regular monitoring of blood pressure and periodic hormone level assessment to evaluate treatment effectiveness and adjust therapy.
monitoringDiagnostic Testing for Underlying Cause
Comprehensive endocrine workup including genetic testing if congenital adrenal hyperplasia is suspected to guide definitive treatment.
procedureBlood Pressure Management
Lifestyle modifications including weight management, regular physical activity, and stress reduction to support cardiovascular health.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Deoxycorticosterone Level C4477025?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Endocrine Society. Clinical Practice Guideline for the Diagnosis and Treatment of Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. 2018;103(7):2449-2469.
Miller WL, Auchus RJ. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev. 2011;32(1):81-151.
Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020.
White PC. Disorders of aldosterone synthesis and action. N Engl J Med. 1994;331(4):250-258.
Biglieri EG, Slaton PE Jr, Schambelan M, Kronfield SJ. Hypermineralocorticoidism. Am J Med. 1968;45(1):170-175.
Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2016;101(5):1889-1916.
Strott CA. Steroid 11 beta-hydroxylase deficiency and related disorders. Endocrinol Metab Clin North Am. 1994;23(2):325-339.
Speiser PW, Arlt W, Auchus RJ, et al. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(11):4043-4088.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy