Abnormal Circulating Globulin Concentration C5139176
This refers to abnormal levels of globulin proteins in the blood, which are important for immune function and transport. It may signal liver, kidney, or immune disorders. Treatment depends on the underlying cause.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Confusion or difficulty concentrating
Mental clouding, trouble focusing, or memory problems.
Seek immediate care if confusion comes on suddenly or is accompanied by vision changes.
Persistent fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest.
Frequency: 70-80% of patients
Frequent infections
(immunologic)Recurring bacterial, viral, or fungal infections due to impaired immune function.
Frequency: 60-70% of patients
Easy bruising or bleeding
(hematologic)Bruises appearing with minimal trauma or prolonged bleeding from cuts.
Frequency: 40-50% of patients
Bone pain
(musculoskeletal)Persistent pain in the back, hips, ribs, or limbs due to bone involvement.
Frequency: 30-40% of patients
Unexplained weight loss
(constitutional)Significant weight loss without changes in diet or exercise.
Frequency: 30-40% of patients
Nausea and loss of appetite
(gastrointestinal)Feeling sick to the stomach with reduced desire to eat.
Frequency: 15-20% of patients
Blurred vision
(neurologic)Vision becoming hazy or out of focus, sometimes with double vision.
Frequency: 5-10% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling winded with minimal exertion.
Frequency: 15-20% of patients
Swollen lymph nodes
(lymphatic)Enlarged lymph nodes in the neck, armpits, or groin.
Frequency: 15-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Globulin fractionation and cause identification
Detailed protein electrophoresis to identify which globulin fraction is abnormal and guide specific diagnostic workup for underlying conditions such as inflammation, infection, or immune disorders.
Treatment of underlying inflammatory condition
Targeted anti-inflammatory or immunosuppressive therapy when elevated globulins are driven by autoimmune or inflammatory diseases such as rheumatoid arthritis or lupus.
Additional treatment options
Anti-inflammatory nutrition
Dietary approach emphasizing whole foods, omega-3 fatty acids, and antioxidants to support immune balance and reduce chronic inflammation that may elevate globulin levels.
dietaryRegular physical activity
Moderate regular exercise to support immune function, reduce systemic inflammation, and improve overall health outcomes related to globulin abnormalities.
lifestyleImmune system support evaluation
Assessment and optimization of nutrients supporting immune function including vitamin D, zinc, and adequate protein intake to help normalize globulin production.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Globulin Concentration C5139176?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
International Myeloma Working Group. IMWG Recommendations for the Diagnosis and Management of Multiple Myeloma. Lancet Oncology. 2021.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Multiple Myeloma. Version 4.2023.
Kyle RA, Rajkumar SV. Multiple Myeloma. New England Journal of Medicine. 2008;358(5):2545-2556.
International Myeloma Working Group. Criteria for the Classification of Monoclonal Gammopathies. Journal of Clinical Oncology. 2003;21(6):1234-1243.
Hoffbrand AV, Higgs PE, Keeling DM. Essential Haematology. 7th ed. Wiley-Blackwell; 2021.
Anderson KC, Auclair D, Anderson J, et al. The Role of Minimal Residual Disease Testing in Multiple Myeloma Treatment Decisions and Risk Stratification: A Consensus Statement from the IMWG. Leukemia. 2023;37(1):30-40.
Mateos MV, Kumar S, Dimopoulos MA, et al. Daratumumab Plus Lenalidomide and Dexamethasone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma: MAIA Trial. Journal of Clinical Oncology. 2020;38(25):2770-2780.
American Society of Hematology. ASH Clinical Practice Guidelines on Plasma Cell Dyscrasias. Blood Advances. 2020;4(12):2744-2758.
Dispenzieri A, Kyle RA. Monoclonal Gammopathy of Undetermined Significance and Waldenström's Macroglobulinemia. Hematology/Oncology Clinics. 2020;34(5):839-851.
World Health Organization. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. IARC Press; 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy