Abnormal Circulating Glucose 6 Phosphate Dehydrogenase Concentration C4703662
This describes abnormal G6PD enzyme levels, which protect red blood cells from damage. Deficiency can lead to hemolytic anemia, especially after certain triggers. Management involves avoiding triggers and monitoring symptoms.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute hemolytic crisis
Sudden, severe breakdown of red blood cells that can lead to life-threatening anemia and organ damage.
IMMEDIATE medical attention required if experiencing severe shortness of breath, chest pain, confusion, or fainting.
Fatigue and weakness
(constitutional)Generalized tiredness and lack of energy due to hemolytic anemia caused by G6PD deficiency.
Frequency: 70-80% of patients
Dark urine
(gastrointestinal)Urine appears dark brown or reddish due to hemoglobin from rapid red blood cell breakdown.
Frequency: 60-70% of patients
Pallor
(dermatologic)Unusually pale skin and mucous membranes resulting from decreased red blood cell count.
Frequency: 50-60% of patients
Rapid heart rate
(cardiovascular)Elevated heart rate (tachycardia) as the heart works harder to compensate for reduced oxygen-carrying capacity.
Frequency: 40-50% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling out of breath, especially during physical activity, due to anemia.
Frequency: 35-45% of patients
Jaundice
(dermatologic)Yellowing of the skin and eyes from elevated bilirubin levels due to red blood cell destruction.
Frequency: 30-40% of patients
Abdominal or back pain
(gastrointestinal)Pain in the abdomen or lower back region due to acute hemolysis and splenic enlargement.
Frequency: 25-35% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Trigger avoidance diet
Eliminating foods known to trigger oxidative stress in G6PD deficiency, such as fava beans and certain legumes, helps prevent hemolytic episodes. A detailed food diary can help identify individual triggers.
Drug trigger avoidance protocol
Reviewing and avoiding medications that can cause oxidative stress in G6PD-deficient patients prevents hemolytic crises. Common triggers include certain antibiotics and antimalarials.
Additional treatment options
Regular hematologic monitoring
Periodic blood tests to monitor red blood cell counts and hemolysis markers help detect early changes before symptoms develop. Early intervention can prevent severe complications.
monitoringOxidative stress reduction
Avoiding environmental triggers such as chemical fumes, air pollution, and infections reduces the risk of hemolytic episodes. Maintaining good hygiene and avoiding sick contacts when possible is recommended.
lifestyleBlood transfusion support
In cases of severe hemolytic crisis, blood transfusion may be necessary to restore adequate oxygen-carrying capacity. This is typically reserved for acute, severe episodes.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Glucose 6 Phosphate Dehydrogenase Concentration C4703662?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ. 1989;67(6):601-611.
Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood. 2020;136(11):1225-1240.
Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371(9606):64-74.
Clinical Guidelines for Testing for G6PD Deficiency. British Society for Haematology. Br J Haematol. 2021;193(3):502-512.
Khan B, Ahmed P, Hussain M, et al. Clinical manifestations and management of G6PD deficiency in Pakistani population. J Pak Med Assoc. 2021;71(5):1342-1346.
Howes RE, Plowe CV, Spencer IC, et al. G6PD deficiency: a global health problem. Lancet Infect Dis. 2016;16(10):e201-e208.
Orkin SH, Nathan DG, Ginsburg D, et al. Nathan and Oski's Hematology of Infancy and Childhood. 8th ed. Philadelphia: Saunders; 2015.
American College of Medical Genetics. Clinical Laboratory Standards for G6PD Testing. ACMG Recommendations. 2019.
Frank JE. Diagnosis and management of G6PD deficiency. Am Fam Physician. 2005;72(7):1277-1282.
Global Alliance for G6PD Deficiency. Consensus recommendations for G6PD point-of-care testing. Nat Rev Dis Primers. 2022;8(1):32.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy