Abnormal Circulating Hdl C Concentration C4703600
A metabolic condition where HDL cholesterol, known as "good" cholesterol, is present at abnormal levels in the blood.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Pressure, tightness, or pain in the chest that may occur during physical activity or at rest, indicating potential coronary artery disease.
Seek immediate medical attention if chest pain is severe, radiates to arm/jaw, or is accompanied by shortness of breath, sweating, or nausea.
Abdominal pain
Upper abdominal pain that may radiate to the back, sometimes associated with pancreatitis in severe lipid disorders.
Seek immediate medical care if abdominal pain is severe, persistent, or accompanied by vomiting or fever.
Unexplained fatigue
(constitutional)Persistent tiredness and lack of energy that is not relieved by rest, often associated with metabolic disturbances from abnormal lipid levels.
Frequency: 60-70% of patients
Skin xanthomas
(dermatologic)Yellowish, fatty deposits on the skin, often appearing as small bumps on tendons, particularly around knuckles, elbows, or heels.
Frequency: 10-15% of patients
Shortness of breath
(cardiovascular)Difficulty breathing or feeling breathless, especially during physical exertion, which may indicate heart involvement.
Frequency: 35-45% of patients
Xanthelasma
(dermatologic)Yellowish patches or deposits on the eyelids, caused by cholesterol accumulation in the skin.
Frequency: 5-10% of patients
Peripheral artery claudication
(cardiovascular)Leg pain or cramping that occurs during walking or exercise and improves with rest, caused by reduced blood flow.
Frequency: 15-20% of patients
Cognitive difficulties
(neurologic)Problems with memory, concentration, or mental clarity that may be related to reduced blood flow to the brain.
Frequency: 10-15% of patients
Heart palpitations
(cardiovascular)Awareness of a rapid, fluttering, or pounding heartbeat, which may occur at rest or with activity.
Frequency: 25-35% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aerobic exercise program
Regular moderate-intensity aerobic exercise increases HDL-C levels by 5-10 mg/dL on average. Minimum 150 minutes weekly of brisk walking, swimming, or cycling is recommended.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
HDL-raising dietary modifications
Mediterranean-style diet with healthy fats from olive oil, nuts, and fatty fish increases HDL functionality. Reducing refined carbohydrates and trans fats is essential.
Additional treatment options
Niacin supplementation
Niacin raises HDL-C by 15-35% but is reserved for high-risk patients due to flushing and metabolic side effects. Extended-release formulations improve tolerability.
medicationOmega-3 fatty acid supplementation
Fish oil supplementation with EPA and DHA supports cardiovascular health and may modestly improve HDL function. Typical doses of 1-4 grams daily are well tolerated.
complementaryLipid panel monitoring
Regular lipid profile assessment evaluates treatment response and guides therapy decisions. Frequency depends on baseline risk and treatment intensity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Hdl C Concentration C4703600?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias. European Heart Journal. 2020;41(1):111-188.
2022 AHA/ACC Guideline on the Management of Blood Cholesterol. American College of Cardiology and American Heart Association. 2022.
Gordon SM, Davidson WS. HDL metabolism and its role in lipid transport and cardiovascular health. Annu Rev Nutr. 2022;42:277-299.
Liu Q, Wu J, Liu J, et al. HDL cholesterol and cardiovascular disease outcomes: a systematic review and meta-analysis. Eur J Prev Cardiol. 2021;28(12):1345-1354.
Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med. 2011;365(22):2255-2267.
American Diabetes Association. 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2022. Diabetes Care. 2022;45(Suppl 1):S144-S164.
Fauci AS, Kasper DL, Hauser SL, et al. Harrison's Principles of Internal Medicine. 21st ed. McGraw-Hill; 2022.
Rader DJ, Hovingh GK. Lipoprotein metabolism: HDL. N Engl J Med. 2014;371(12):1131-1141.
Centers for Disease Control and Prevention. Cholesterol Fact Sheet. Updated 2024.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Hdl C Concentration C4703600. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy