Abnormal Circulating Interferon Gamma Concentration C4072899
Abnormal levels of a specific immune protein important for fighting infections and regulating inflammation. Can affect immunity and autoimmune responses. Specialist evaluation recommended.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever
Elevated body temperature often accompanied by warmth to touch and sweating.
Seek immediate care if fever exceeds 103°F (39.4°C) or is accompanied by severe chills, confusion, or difficulty breathing.
Recurrent infections
Frequent bacterial, viral, or fungal infections due to impaired immune function.
Seek urgent care if experiencing severe infections, fever with infection symptoms, or infections that don't respond to standard treatment.
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 60-80% of patients
Muscle aches
(constitutional)Generalized muscle pain and soreness affecting multiple muscle groups.
Frequency: 40-60% of patients
Night sweats
(constitutional)Excessive sweating during sleep that may soak through clothing or bedding.
Frequency: 35-55% of patients
Weight loss
(constitutional)Unintentional loss of body weight without dietary changes or increased physical activity.
Frequency: 30-50% of patients
Headache
(neurologic)Persistent or recurring head pain that may vary in intensity and location.
Frequency: 30-45% of patients
Skin rash
(dermatologic)Abnormal skin changes including redness, patches, or lesions that may be itchy or painful.
Frequency: 15-25% of patients
Shortness of breath
(respiratory)Difficulty breathing or feeling breathless, especially during physical activity or at rest.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Cellular Immunity Evaluation
Assess for conditions associated with interferon-gamma dysregulation including chronic granulomatous disease, Mendelian susceptibility to mycobacterial disease, or autoimmune conditions. Repeat testing may clarify persistent abnormalities.
Interferon-Gamma Replacement Therapy
For confirmed interferon-gamma deficiency with recurrent infections, recombinant interferon-gamma therapy may be considered under specialist guidance to restore cell-mediated immunity and improve infection resistance.
Additional treatment options
Antimicrobial Prophylaxis
If interferon-gamma dysfunction predisposes to specific infections such as mycobacteria, prophylactic antimicrobials may be indicated. Choice depends on identified pathogens and regional resistance patterns.
medicationImmunonutrition Support
Ensure adequate intake of nutrients supporting immune function including zinc, selenium, vitamin D, and omega-3 fatty acids. Deficiencies in these nutrients can compound immune dysfunction.
dietaryInfection Prevention Measures
Implement practical measures to reduce infection exposure including hand hygiene, food safety practices, and avoiding contact with obviously ill individuals when possible.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Interferon Gamma Concentration C4072899?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. Guidelines on interferon-gamma release assays for tuberculosis infection. WHO Guidelines Repository. 2018.
Schroder K, Hertzog PJ, Ravasi T, Hume DA. Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology. 2004;75(2):163-189.
Miller PW, Sharma S, Stolina M, et al. Intratumoral administration of IL-12 plasmid DNA by in vivo electroporation. Cancer Research. 2001;61(8):3281-3284.
Du Y, Chen L, Cai C, et al. Diagnostic value of interferon-gamma release assay for active pulmonary tuberculosis: a meta-analysis. Clinical Respiratory Journal. 2017;11(6):749-759.
Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. Garland Science; 2001.
American Academy of Allergy, Asthma and Immunology. Practice parameters for the diagnosis and treatment of primary immunodeficiencies. Journal of Allergy and Clinical Immunology. 2014;134(5):S1-S49.
International Union of Immunological Societies. Primary immunodeficiency diseases: a WHO-led global effort. Clinical and Experimental Immunology. 2019;198(1):1-3.
Kak G, Raza M, Tiwari BK. Interferon-gamma (IFN-γ): exploring its implications in infectious diseases. Biomolecular Concepts. 2018;9(1):64-79.
Centers for Disease Control and Prevention. Testing for TB Infection. CDC Guidelines. 2022.
Stern M, Heterich S, Tappeiner P, et al. Serum cytokine profiles in patients with chronic granulomatous disease. Frontiers in Immunology. 2018;9:2032.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy