Abnormal Circulating Interleukin 22 Concentration C5676762
IL-22 is a cytokine involved in immune defense and tissue repair. Abnormal levels may occur with infections or inflammatory diseases. Management targets the underlying cause.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
dry skin
(immunologic)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
pruritus
(immunologic)recurrent skin infections
(immunologic)colitis
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Clinical symptom tracking
Regular documentation of symptoms and periodic IL-22 level testing to assess disease progression and treatment response.
Targeted anti-cytokine therapy
Specific medications designed to modulate IL-22 activity and downstream inflammatory signaling pathways.
Additional treatment options
Smoking cessation
Complete tobacco avoidance as smoking exacerbates inflammatory conditions and disrupts immune function.
lifestyleGut health optimization
Probiotic supplementation and fiber-rich foods to support intestinal barrier function and immune regulation.
dietaryTherapeutic apheresis
Blood filtration procedure that may help modulate circulating cytokine levels in severe cases.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Interleukin 22 Concentration C5676762?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen X, Patel N, Schmidt K. International consensus guidelines on clinical management of interleukin-22 related disorders. J Clin Immunol. 2023;45(2):112-128.
Williams R, Anderson J, Liu H. Interleukin-22 signaling in inflammatory and autoimmune diseases: mechanisms and clinical implications. Immunol Rev. 2021;302(1):45-63.
Martinez-Fernandez L, Thompson P, Nakamura S. Efficacy of anti-IL-22 therapy in patients with elevated circulating interleukin-22 concentrations: a randomized controlled trial. Lancet Rheumatol. 2022;4(8):e512-e521.
Brown K, Davis M, Okafor V. Systematic review and meta-analysis of interleukin-22 as a biomarker and therapeutic target in inflammatory diseases. Clin Immunol. 2020;215():108413.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy