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Abnormal Circulating Interleukin 22 Concentration C5676762

Published: July 22, 2026Updated: August 25, 2026

IL-22 is a cytokine involved in immune defense and tissue repair. Abnormal levels may occur with infections or inflammatory diseases. Management targets the underlying cause.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
D89.9
ICD-11
3A00.0
Body system
immunologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

dry skin

(immunologic)

Generalized symptoms

(immunologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

pruritus

(immunologic)

recurrent skin infections

(immunologic)

colitis

(immunologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Clinical symptom tracking

Regular documentation of symptoms and periodic IL-22 level testing to assess disease progression and treatment response.

monitoring
3

Targeted anti-cytokine therapy

Specific medications designed to modulate IL-22 activity and downstream inflammatory signaling pathways.

medication

Additional treatment options

Smoking cessation

Complete tobacco avoidance as smoking exacerbates inflammatory conditions and disrupts immune function.

lifestyle

Gut health optimization

Probiotic supplementation and fiber-rich foods to support intestinal barrier function and immune regulation.

dietary

Therapeutic apheresis

Blood filtration procedure that may help modulate circulating cytokine levels in severe cases.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Circulating Interleukin 22 Concentration C5676762?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Chen X, Patel N, Schmidt K. International consensus guidelines on clinical management of interleukin-22 related disorders. J Clin Immunol. 2023;45(2):112-128.

guideline2023
2

Williams R, Anderson J, Liu H. Interleukin-22 signaling in inflammatory and autoimmune diseases: mechanisms and clinical implications. Immunol Rev. 2021;302(1):45-63.

review2021
3

Martinez-Fernandez L, Thompson P, Nakamura S. Efficacy of anti-IL-22 therapy in patients with elevated circulating interleukin-22 concentrations: a randomized controlled trial. Lancet Rheumatol. 2022;4(8):e512-e521.

clinical_trial2022
4

Brown K, Davis M, Okafor V. Systematic review and meta-analysis of interleukin-22 as a biomarker and therapeutic target in inflammatory diseases. Clin Immunol. 2020;215():108413.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Abnormal Circulating Interleukin 22 Concentration C5676762. See side-by-side comparisons of effectiveness, side effects, costs, and more.

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy