Abnormal Circulating Luteinizing Hormone Concentration C0580438
Luteinizing hormone regulates reproduction and hormone balance. Abnormal levels can affect menstrual cycles, fertility, or puberty. Treatment depends on the underlying cause.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe pelvic pain
Intense pain in the lower abdomen or pelvis that may indicate ovarian cysts, torsion, or other complications.
Seek immediate emergency care for sudden, severe pelvic pain or pain with fever, vomiting, or fainting.
Menstrual irregularities
(reproductive)Changes in menstrual cycle timing, flow amount, or duration; may include missed periods, infrequent periods, or unpredictable bleeding patterns.
Frequency: 70-80% of patients
Infertility
(reproductive)Frequency: 60-70% of patients
Hot flashes
(constitutional)Sudden feelings of intense heat, often with sweating and flushing, typically affecting the face, neck, and chest.
Frequency: 40-50% of patients
Decreased libido
(reproductive)Reduced interest in sexual activity due to hormonal changes affecting sexual desire and function.
Frequency: 35-45% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that is not relieved by rest, often impacting daily activities.
Frequency: 30-40% of patients
Mood changes
(neurologic)Emotional fluctuations including irritability, anxiety, sadness, or difficulty concentrating due to hormonal imbalances.
Frequency: 25-35% of patients
Abnormal uterine bleeding
(reproductive)Unusual vaginal bleeding outside the normal menstrual pattern, including spotting, heavy bleeding, or bleeding between periods.
Frequency: 25-35% of patients
Excessive hair growth
(dermatologic)Increased hair growth in areas such as face, chest, back, or abdomen, often coarse and dark (hirsutism).
Frequency: 20-30% of patients
Acne and skin changes
(dermatologic)Breakouts of pimples, oily skin, or other skin manifestations, particularly on face, chest, and upper back.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Hormone regulation therapy
Pharmacological agents that modulate hypothalamic-pituitary-gonadal axis function to normalize LH secretion patterns.
Hormonal profile monitoring
Serial LH and related hormone measurements to evaluate treatment response and adjust therapeutic interventions.
Additional treatment options
Stress reduction techniques
Mindfulness-based interventions and stress management to reduce cortisol-mediated suppression of gonadotropin release.
lifestyleNutritional optimization
Balanced diet supporting endocrine function with adequate protein, healthy fats, and micronutrients essential for hormone synthesis.
dietaryReproductive health counseling
Psychological support addressing fertility concerns and body image issues that commonly accompany hormonal imbalances.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Luteinizing Hormone Concentration C0580438?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Practice Committee of the American Society for Reproductive Medicine. Evidence-based outcomes for infertility treatment: luteinizing hormone measurement and its clinical utility. Fertil Steril. 2023;119(5):742-758.
Endocrine Society. Clinical practice guidelines for evaluation of amenorrhea and abnormal uterine bleeding. J Clin Endocrinol Metab. 2022;107(5):1233-1249.
Tsatsoulis A, Kutilidou M, Koliakos G. Luteinizing hormone: physiology and clinical significance. Ann N Y Acad Sci. 2020;1483(1):81-95.
Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: a meta-analysis. Hum Reprod Update. 2021;27(2):199-250.
Miller WL, Auchus RJ. The molecular biology, biochemistry, and physiology of human steroidogenesis. J Clin Endocrinol Metab. 2021;106(3):687-698.
International Hormone Society. Position statement on the diagnosis and management of hypogonadotropic hypogonadism. Int J Endocrinol Metab. 2019;17(4):e84621.
WHO Technical Report Series. WHO standard for international standardization of hormone measurements. Geneva: World Health Organization; 2019.
Melmed S, Koenig R, Rosen C, Auchus R, Goldfine A, editors. Williams Textbook of Endocrinology. 14th ed. Philadelphia: Elsevier; 2020.
Hall JE. Endocrinology of the menopause. Endocrinol Metab Clin North Am. 2019;48(3):485-498.
American College of Obstetricians and Gynecologists. Evaluation and management of abnormal uterine bleeding. Obstet Gynecol. 2020;135(1):e49-e68.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy