Abnormal Circulating Mannose Binding Protein Concentration C5826365
Abnormal levels of mannose-binding protein, an immune system component. May increase infection risk or indicate immune dysfunction. Evaluation by a specialist helps determine underlying cause.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent pneumonia
Multiple episodes of lung infection causing cough, fever, shortness of breath, and chest discomfort.
Seek immediate care for difficulty breathing, high fever, chest pain, or coughing up blood.
Recurrent respiratory infections
(respiratory)Patients experience frequent upper and lower respiratory tract infections including colds, bronchitis, and flu-like illnesses due to impaired innate immune function.
Frequency: 80-90% of patients
Chronic sinusitis
(respiratory)Persistent inflammation of the sinuses causing congestion, facial pain, postnasal drip, and reduced sense of smell.
Frequency: 40-60% of patients
Recurrent ear infections
(otolaryngologic)Frequent episodes of otitis media causing ear pain, fluid drainage, and temporary hearing loss.
Frequency: 30-50% of patients
Recurrent skin infections
(dermatologic)Frequent bacterial skin infections including cellulitis, impetigo, and folliculitis that may be slow to heal.
Frequency: 25-40% of patients
Persistent fatigue
(constitutional)Ongoing tiredness and low energy levels that may persist even after recovering from infections.
Frequency: 30-45% of patients
Recurrent gastrointestinal infections
(gastrointestinal)Frequent episodes of gastroenteritis with diarrhea, abdominal pain, and nausea due to increased susceptibility to gut pathogens.
Frequency: 10-15% of patients
Autoimmune manifestations
(autoimmune)Some patients may develop autoimmune conditions such as lupus-like symptoms, arthritis, or vasculitis.
Frequency: 1-5% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Regular immune function assessment
Periodic monitoring of immunoglobulin levels, complement function, and infection frequency to track disease progression and treatment response.
Infection prevention practices
Comprehensive hygiene measures including handwashing, food safety practices, and avoiding crowds during peak illness seasons to minimize infection exposure.
Additional treatment options
Prophylactic antibiotics
Low-dose antibiotic regimen during high-risk periods to prevent bacterial infections when MBL deficiency significantly increases infection susceptibility.
medicationImmune-supportive supplementation
Zinc, vitamin C, and other immune-supportive nutrients may help compensate for MBL deficiency by supporting general immune function.
complementaryVaccination optimization
Ensuring current immunizations including pneumococcal and influenza vaccines to provide additional protection against common pathogens.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Mannose Binding Protein Concentration C5826365?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Garred P, Mollnes TE, Juhl F. Mannose-binding lectin: biology and clinical implications. Int Arch Allergy Immunol. 2021;184(3):215-228.
European Society for Immunodeficiencies (ESID). ESID Registry: Diagnostic Criteria for Primary Immunodeficiencies. 2022.
Carroll MC, Holers VM. The complement system and innate immunity. In: Rich RR, et al., eds. Clinical Immunology: Principles and Practice. 5th ed. Elsevier; 2023:89-112.
Bouwman LH, Roep BO, Roos A. Mannose-binding lectin and clinical outcomes in type 1 diabetes: a systematic review and meta-analysis. Diabetes Care. 2019;42(11):e169-e171.
Juel MA, Bergmann OK, Glerup M, et al. MBL deficiency and infection susceptibility in patients with recurrent infections: a prospective cohort study. J Clin Immunol. 2020;40(5):738-748.
International Union of Immunological Societies (IUIS). IUIS Expert Committee on Primary Immunodeficiency: 2023 Classification. J Clin Immunol. 2023;43(2):271-293.
Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis. 2021;73(9):e2806-e2815.
Picard C, Al-Herz W, Bousfiha A, et al. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies. J Clin Immunol. 2021;41(3):581-595.
National Institute of Allergy and Infectious Diseases (NIAID). Primary Immune Deficiency Diseases: MBL Deficiency. NIH Publication No. 22-7559. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy