Abnormal Circulating Monocarboxylic Acid Concentration C5706139
Abnormal levels of monocarboxylic acids like lactate in the blood. Can signal metabolic disturbances or tissue oxygen problems. Treatment focuses on addressing the underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Sudden uncontrolled electrical disturbances in the brain due to severe metabolic derangement affecting neuronal function.
This is a medical emergency. Call emergency services immediately if a seizure occurs.
Loss of Consciousness
Fainting or unresponsiveness resulting from severe acidosis, electrolyte abnormalities, or cerebral hypoperfusion.
This is a medical emergency. Call emergency services immediately.
Fatigue and Weakness
(constitutional)Persistent feeling of tiredness and general body weakness due to metabolic acidosis affecting cellular energy production.
Frequency: 80-90% of patients
Nausea and Vomiting
(gastrointestinal)Feeling sick to the stomach with possible vomiting, resulting from acid buildup affecting the digestive system.
Frequency: 70-80% of patients
Rapid Breathing
(respiratory)Increased breathing rate (Kussmaul respirations) as the body attempts to compensate for metabolic acidosis by expelling carbon dioxide.
Frequency: 75-85% of patients
Confusion and Disorientation
(neurologic)Mental confusion, difficulty concentrating, or feeling disoriented due to acidosis affecting brain function.
Frequency: 50-60% of patients
Abdominal Pain
(gastrointestinal)General or localized abdominal discomfort associated with metabolic disturbance affecting abdominal organs.
Frequency: 40-50% of patients
Muscle Weakness and Cramps
(musculoskeletal)Reduced muscle strength and painful cramps resulting from electrolyte imbalances secondary to metabolic acidosis.
Frequency: 35-45% of patients
Irregular Heartbeat
(cardiovascular)Heart rhythm disturbances (arrhythmias) caused by electrolyte imbalances and acidosis affecting cardiac function.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Low-carbohydrate diet modification
Restricting intake of fermentable carbohydrates and adjusting macronutrient ratios to reduce accumulation of short-chain fatty acids and monocarboxylic acids. Regular meal timing helps normalize acid metabolism.
Bicarbonate supplementation
Oral sodium bicarbonate or other alkali therapy to correct metabolic acidosis when pH drops below normal range. Long-term management requires regular electrolyte monitoring.
Additional treatment options
Serum acid-base and organic acid panel
Regular laboratory assessment of circulating monocarboxylic acid levels and acid-base balance to guide treatment adjustments and identify triggering factors.
monitoringAerobic exercise conditioning
Moderate-intensity regular exercise to improve metabolic efficiency and acid clearance through enhanced circulation and cellular respiration pathways.
lifestyleProbiotic supplementation
Gut microbiome modulation through probiotic therapy may influence short-chain fatty acid production and improve overall metabolic homeostasis.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy