Abnormal Circulating Progesterone Level C4531274
A condition where progesterone hormone levels in the blood are abnormal, which can cause menstrual irregularities, fertility problems, or pregnancy complications. It affects women of reproductive age. Treatment often involves hormone therapy to restore balance.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abnormal uterine bleeding
Unexpected vaginal bleeding between periods or unusually heavy menstrual flow.
Seek immediate medical attention if experiencing heavy bleeding, bleeding after menopause, or bleeding during pregnancy.
Severe abdominal pain
Intense, persistent abdominal pain that may indicate ectopic pregnancy or ovarian cyst complications.
Seek emergency care immediately for sudden, severe abdominal or pelvic pain, especially if accompanied by dizziness or fainting.
Menstrual irregularities
(reproductive)Changes in menstrual cycle timing, flow, or duration due to hormonal imbalance affecting the endometrium.
Frequency: 70-80% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that interferes with daily activities.
Frequency: 60-70% of patients
Mood changes
(neurologic)Emotional fluctuations including anxiety, irritability, or depression related to hormonal shifts.
Frequency: 40-50% of patients
Breast tenderness
(reproductive)Increased sensitivity or pain in breast tissue due to hormonal effects on mammary glands.
Frequency: 30-40% of patients
Bloating
(gastrointestinal)Feeling of fullness or swelling in the abdomen caused by fluid retention and digestive changes.
Frequency: 30-40% of patients
Infertility
(reproductive)Difficulty conceiving due to inadequate progesterone support for ovulation and embryo implantation.
Frequency: 25-35% of patients
Sleep disturbances
(neurologic)Difficulty falling asleep, staying asleep, or experiencing restful sleep due to hormonal imbalance.
Frequency: 25-35% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Progesterone supplementation
Exogenous progesterone therapy to correct deficiency affecting menstrual cycles, fertility, or pregnancy maintenance. Various formulations available including oral, vaginal, and injectable preparations.
Hormone level tracking
Serial progesterone measurements timed appropriately in menstrual cycle to assess treatment response and guide dosage adjustments. Mid-luteal levels typically monitored.
Additional treatment options
Clomiphene citrate
Ovulation induction agent for women with abnormal progesterone due to anovulation. Stimulates follicular development and subsequent corpus luteum progesterone production.
medicationWeight optimization
Achieving healthy body weight as adipose tissue affects estrogen-to-progesterone balance. Both obesity and low body fat can disrupt progesterone metabolism.
lifestyleVitex supplementation
Traditional herbal approach using chaste tree berry to support progesterone through effects on pituitary function. Evidence primarily from historical use rather than rigorous trials.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Progesterone Level C4531274?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American College of Obstetricians and Gynecologists. Practice Bulletin No. 141: Management of Menopausal Symptoms. Obstet Gynecol. 2014;123(1):202-216.
Stuenkel CA, Davis SR, Gompel A, et al. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(11):3975-4011.
World Health Organization. WHO Recommendation: Progesterone for Women with Threatened Miscarriage. Geneva: WHO; 2021.
Saccone G, Khalifeh A, Al-Kouatly HB, et al. Supplemental progesterone for prevention of recurrent preterm birth: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021;225(2):139-151.
Di Renzo GC, Tosto V, Giardina I. The biological basis for and the benefits of progesterone in preventing preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:23-32.
American College of Obstetricians and Gynecologists. Committee Opinion No. 764: Medically Indicated Late-Preterm and Early-Term Deliveries. Obstet Gynecol. 2019;133(2):e151-e164.
Norman JE, Marlow N, Messow CM, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016;387(10033):2106-2116.
Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 14th ed. Elsevier; 2019.
Graham JD, Clarke CL. Physiological action of progesterone in target tissues. Endocr Rev. 1997;18(4):502-519.
Fritz MA, Speroff L. Clinical Gynecologic Endocrinology and Infertility. 9th ed. Wolters Kluwer; 2020.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Progesterone Level C4531274. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy