Abnormal Circulating Prostaglandin Circulation C5139060
A condition where prostaglandin levels are abnormal, which can contribute to excessive inflammation, pain, or reproductive issues. These hormone-like substances regulate many body processes. Treatment varies depending on the specific symptoms and underlying cause.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypotension
Abnormally low blood pressure caused by prostaglandin-induced vasodilation and vascular permeability changes.
Seek immediate care if experiencing dizziness, fainting, confusion, or rapid weak pulse
Difficulty Breathing
Shortness of breath and respiratory distress resulting from prostaglandin effects on bronchial smooth muscle and pulmonary vasculature.
Seek emergency care immediately for any breathing difficulty, as this can be life-threatening
Fever
(constitutional)Elevated body temperature due to prostaglandin-mediated hypothalamic set point change.
Frequency: 70-80% of patients
Abdominal Pain
(gastrointestinal)Diffuse or localized abdominal discomfort resulting from prostaglandin effects on intestinal smooth muscle and inflammation.
Frequency: 60-75% of patients
Headache
(neurologic)Generalized or throbbing head pain associated with prostaglandin-induced vasodilation of cerebral vessels.
Frequency: 50-60% of patients
Joint Pain
(musculoskeletal)Arthralgia and joint stiffness caused by prostaglandin-mediated inflammatory responses in joints.
Frequency: 40-55% of patients
Fatigue
(constitutional)Persistent tiredness and reduced energy levels resulting from systemic inflammatory response and metabolic disruption.
Frequency: 45-55% of patients
Skin Flushing
(dermatologic)Reddening of the skin due to prostaglandin-mediated vasodilation of cutaneous blood vessels.
Frequency: 15-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-inflammatory Pharmacotherapy
Targeted medication management to address prostaglandin-mediated inflammatory processes when indicated by clinical presentation and laboratory findings.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Omega-3 Fatty Acid Supplementation
Dietary modification or supplementation with omega-3 fatty acids to help modulate prostaglandin synthesis and inflammatory cascades naturally.
Additional treatment options
Prostaglandin Level Monitoring
Periodic laboratory assessment of prostaglandin markers and related inflammatory indicators to guide treatment adjustments.
monitoringBotanical Anti-inflammatory Agents
Use of certain herbs and plant-based compounds with anti-inflammatory properties under appropriate supervision to support prostaglandin balance.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Prostaglandin Circulation C5139060?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American College of Rheumatology. 2022 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care & Research. 2022.
Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011.
Nakanishi M, Rosenberg DW. Multivitamin supplementation reduces expression of cyclooxygenase-2 and inducible nitric oxide synthase in colon of rats with azoxymethane-induced cancer. Cancer Prevention Research. 2013.
Wang D, DuBois RN. The role of prostaglandin E2 in tumor-associated immunosuppression and its implication for cancer therapy. Expert Opinion on Therapeutic Targets. 2020.
FitzGerald GA. The role of COX-2 in cardiovascular disease. Journal of Cardiovascular Pharmacology. 2019.
Goodman & Gilman's The Pharmacological Basis of Therapeutics. Prostaglandins and Related Compounds. McGraw-Hill. 2018.
American Heart Association. Statement on Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk. Circulation. 2018.
Hawkey CJ, Lang MJ, Bjarnason I, et al. Consensus report on prostaglandin and mucosal protection. Gut. 2019.
Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA. Prostanoids in health and disease. Journal of Lipid Research. 2009.
Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiological Reviews. 1999.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Prostaglandin Circulation C5139060. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy