Abnormal Circulating Vitamin E Concentration C5826840
An abnormal level of vitamin E in the blood. May result from dietary factors or problems absorbing fats. Typically managed with dietary changes or supplements.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bleeding tendency
Increased tendency to bleed or bruise easily due to impaired blood clotting.
IMMEDIATELY if unusual bleeding, severe bruising, or blood in stool/urine occurs
Peripheral neuropathy
(neurologic)Nerve damage causing numbness, tingling, or burning sensations, typically starting in the hands and feet.
Frequency: 60-70% of patients
Ataxia
(neurologic)Loss of coordination and balance, making walking and fine motor movements difficult.
Frequency: 50-60% of patients
Hemolytic anemia
(hematologic)Premature breakdown of red blood cells leading to fatigue, pale skin, and shortness of breath.
Frequency: 40-50% of patients
Muscle weakness
(musculoskeletal)Generalized muscle weakness, particularly in the legs and arms, affecting physical activity.
Frequency: 40-50% of patients
Retinopathy
(ocular)Damage to the retina causing blurred vision, difficulty seeing in low light, or visual field loss.
Frequency: 10-20% of patients
Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest.
Frequency: 50-60% of patients
Nausea
(gastrointestinal)Feeling of sickness in the stomach with urge to vomit, often after supplement intake.
Frequency: 30-40% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Vitamin E Food Source Incorporation
Add vitamin E-rich foods including nuts, seeds, spinach, broccoli, and vegetable oils to the diet. Natural food sources provide balanced tocopherol forms for optimal utilization.
Tocopherol Ratio Assessment
Advanced lipid panel with vitamin E and tocopherol ratios to fully characterize abnormality and distinguish between deficiency and malabsorption-related issues.
Additional treatment options
Fat Intake Optimization
Ensure adequate healthy fat consumption to support vitamin E absorption, as this fat-soluble vitamin requires dietary fats for optimal bioavailability.
lifestyleAlpha-Tocopherol Supplementation
Pharmaceutical-grade vitamin E supplementation for documented deficiency states, typically in d-alpha-tocopherol form for better bioavailability.
medicationFat Malabsorption Workup
Comprehensive evaluation for conditions causing fat malabsorption including cystic fibrosis, celiac disease, and cholestatic liver conditions that affect vitamin E absorption.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Vitamin E Concentration C5826840?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization/Food and Agriculture Organization. Vitamin and Mineral Requirements in Human Nutrition. WHO Geneva. 2004.
Traber MG. Vitamin E. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Wiley-Blackwell. 2012.
National Institutes of Health Office of Dietary Supplements. Vitamin E Fact Sheet for Health Professionals. NIH. 2021.
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database of Systematic Reviews. 2012.
Singer P, Berger MM, Van den Berghe G, et al. ESPEN Guidelines on Parenteral Nutrition: Intensive care. Clinical Nutrition. 2009;28(4):387-400.
Rizvi S, Raza ST, Ahmed F, et al. The role of vitamin E in human health and some diseases. Sultan Qaboos University Medical Journal. 2014;14(2):e157-e165.
The HOPE and HOPE-TOO Trial Investigators. Vitamin E supplementation and cardiovascular events in high-risk patients. New England Journal of Medicine. 2000;342(3):154-160.
Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, eds. Modern Nutrition in Health and Disease. 10th ed. Lippincott Williams & Wilkins. 2006.
Miller ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of Internal Medicine. 2005;142(1):37-46.
U.S. Department of Agriculture, Agricultural Research Service. FoodData Central. 2023.
Medication Comparisons
Compare medications used to treat Abnormal Circulating Vitamin E Concentration C5826840. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy