Abnormal Circulating Zinc Concentration C4024711
An abnormal level of zinc in the blood. Can result from diet, absorption problems, or certain health conditions. Often corrected with dietary changes or supplements.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Cognitive Changes
Confusion, difficulty concentrating, lethargy, and in severe cases, neurological dysfunction.
Seek immediate medical attention if experiencing confusion, severe lethargy, or difficulty with coordination.
Taste Alteration
(neurologic)Diminished sense of taste (hypogeusia) or metallic taste in the mouth, often leading to reduced appetite.
Frequency: 70-80% of patients
Hair Loss
(dermatologic)Patchy or diffuse hair loss (alopecia) due to impaired hair follicle function.
Frequency: 40-50% of patients
Diarrhea
(gastrointestinal)Loose, watery stools that may be chronic, due to impaired intestinal barrier function.
Frequency: 40-60% of patients
Dermatitis
(dermatologic)Red, scaly, eczematous rash typically around body orifices (mouth, nose, genitals).
Frequency: 30-40% of patients
Delayed Wound Healing
(constitutional)Slow or impaired healing of cuts, wounds, and surgical incisions.
Frequency: 30-40% of patients
Nail Abnormalities
(dermatologic)Brittle, ridged, or white-spotted nails (leukonychia) and nail growth retardation.
Frequency: 25-35% of patients
Nausea and Vomiting
(gastrointestinal)Feeling of nausea with or without vomiting, more common in zinc excess.
Frequency: 15-20% of patients
Growth Retardation
(constitutional)Impaired growth velocity and delayed puberty in children due to zinc's role in growth hormone function.
Frequency: 10-20% of patients
Recurrent Infections
(immunologic)Increased susceptibility to bacterial, viral, and fungal infections due to impaired immune function.
Frequency: 15-25% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Zinc-rich dietary modification
Increase intake of zinc-containing foods such as oysters, red meat, beans, nuts, and whole grains to normalize circulating zinc levels.
Additional treatment options
Zinc level monitoring
Regular blood testing to track zinc concentrations and ensure adequate response to dietary changes or supplementation.
monitoringGut health optimization
Address potential malabsorption issues through probiotics and gut health support to improve zinc absorption.
complementaryPhytic acid reduction strategies
Techniques to reduce phytic acid in foods (soaking, sprouting) to improve zinc bioavailability from plant sources.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Circulating Zinc Concentration C4024711?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Office of Dietary Supplements. Zinc: Fact Sheet for Health Professionals. National Institutes of Health. 2022.
World Health Organization. WHO Guidelines on Food Fortification with Micronutrients. Geneva: WHO. 2016.
Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: An integrative review. J Res Med Sci. 2013;18(2):144-157.
Espinet E, Angelet J, Romero E, et al. Selenium and zinc deficiencies in the critically ill patient: A consensus statement from the ESPEN. Clin Nutr. 2022;41(12):2809-2822.
Liu Y, Yang L, Xu J, et al. Effects of zinc supplementation on circulating concentrations: A systematic review and meta-analysis. Nutrients. 2022;14(8):1627.
Shils ME, Shike M, Ross AC, Caballero B, Cousins RJ, editors. Modern Nutrition in Health and Disease. 11th ed. Philadelphia: Lippincott Williams & Wilkins; 2014.
Walsh K, Sridhar V, Kothari M, et al. Zinc supplementation and metabolic markers in healthy adults: A randomized controlled trial. J Trace Elem Med Biol. 2021;65:126735.
Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academies Press; 2001.
Chasapis CT, Loutsidi AC, Zoupi M, et al. Zinc homeostasis and its role in human health: A comprehensive review. Arch Toxicol. 2022;96(5):1343-1361.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy