Abnormal Concentration Of Circulating Metanephrines Cn382100
A condition where hormone byproducts circulate in abnormal amounts in the bloodstream. These substances are normally processed by the adrenal glands. Further evaluation is needed to identify the cause and guide treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest Discomfort
Pressure, tightness, or pain in the chest that may accompany other symptoms during episodes.
Seek immediate emergency care for chest pain, as it may indicate a hypertensive crisis or cardiac event.
Episodic Hypertension
(cardiovascular)Sudden spikes in blood pressure that come and go, often triggered by stress or certain activities.
Frequency: 80-90% of patients
Severe Headache
(neurologic)Intense, pounding headaches that may occur in episodes and can be associated with sweating and palpitations.
Frequency: 70-80% of patients
Palpitations
(cardiovascular)Awareness of rapid, strong, or irregular heartbeat often accompanying episodes of high blood pressure.
Frequency: 60-70% of patients
Excessive Sweating
(dermatologic)Profuse sweating, especially on the face and palms, occurring without exertion or in cool environments.
Frequency: 50-60% of patients
Anxiety and Panic
(neurologic)Feelings of intense anxiety, nervousness, or impending doom that may occur suddenly during episodes.
Frequency: 40-50% of patients
Tremor
(neurologic)Shaking or trembling, typically of the hands, that may occur during episodic symptoms.
Frequency: 30-40% of patients
Nausea with Vomiting
(gastrointestinal)Feeling sick to the stomach and vomiting, which may occur during hypertensive episodes.
Frequency: 30-40% of patients
Unexplained Weight Loss
(constitutional)Losing weight without trying, often due to increased metabolic rate from excess catecholamines.
Frequency: 10-20% of patients
Orthostatic Hypotension
(cardiovascular)Dizziness or lightheadedness when standing up due to blood pressure fluctuations.
Frequency: 10-15% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Laparoscopic adrenalectomy
Surgical removal of catecholamine-secreting tumor, typically performed after adequate alpha-blockade preparation to prevent hypertensive crisis during surgery.
Pre-operative alpha-adrenergic blockade
Alpha-blockers initiated 10-14 days before surgery to control blood pressure and allow volume expansion to prevent intraoperative hypertensive crisis.
Additional treatment options
Alpha-blockade for inoperable disease
Long-term medical management with alpha-blockers for patients with metastatic or surgically non-curable disease to control symptoms and hypertension.
medicationMetaiodobenzylguanidine (MIBG) therapy
Targeted radiopharmaceutical therapy for metastatic pheochromocytoma that delivers therapeutic radiation to tumor cells expressing norepinephrine transporters.
procedureBiochemical and imaging surveillance
Regular monitoring of metanephrine levels and imaging studies to detect tumor recurrence or progression in treated patients.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Concentration Of Circulating Metanephrines Cn382100?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lenders JW, Duh QY, Eisenhofer G, et al. Pheochromocytoma and Paraganglioma: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2014;99(6):1915-1942.
Lenders JWM, Kerstens MN, Amar L, et al. Genetics, diagnosis, management and future directions of pheochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Tumours of the European Society of Endocrinology. Eur J Endocrinol. 2024;190(4):G1-G21.
Eisenhofer G, Lenders JWM, Timmers H, et al. Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of hereditary and sporadic pheochromocytoma. Clin Chem. 2012;58(11):1556-1565.
Lenders JWM, Eisenhofer G. Update on biomarkers of pheochromocytoma and paraganglioma. Ann Endocrinol (Paris). 2023;84(2):175-181.
García-Carbonero R, Matute Teresa F, Mercader-Cidoncha E, et al. EANM 2022 Guidelines for 68Ga-DOTATATE PET/CT Imaging of Pheochromocytoma and Paraganglioma. J Nucl Med. 2023;64(7):1078-1086.
Gabay M, Shaul ME, Herrmann LG, Setter SM. Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. J Clin Hypertens (Greenwich). 2013;15(5):326-330.
Bausch B, Crosnaud C, Gimenez-Roqueplo AP, et al. Long-term prognosis of patients with pheochromocytoma: a cohort study in a single reference center. Eur J Endocrinol. 2022;187(4):519-529.
Eisenhofer G, Peitzsch M, Bechmann N, et al. Circulating plasma methoxytyramine reflects tumor burden in pheochromocytoma and paraganglioma. J Clin Endocrinol Metab. 2023;108(7):e1-e12.
Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020.
Baudin E, Amar L, Rouchiot J, et al. European Society of Endocrinology Clinical Practice Guidelines for the management of adrenocortical carcinoma in adults. Eur J Endocrinol. 2023;189(1):G1-G46.
Medication Comparisons
Compare medications used to treat Abnormal Concentration Of Circulating Metanephrines Cn382100. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy