Abnormal Csf Glycine Concentration C5139614
This involves abnormal glycine levels in the fluid around the brain and spine. Glycine helps regulate brain signals and plays a role in movement and cognition. Treatment focuses on identifying and managing the underlying cause.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Apnea
Generalized symptoms
(neurologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Seizures
(neurologic)Hypotonia
(neurologic)Intellectual disability
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive metabolic monitoring
Regular assessment of glycine levels and related metabolic markers to establish baseline patterns and detect any progression. Includes periodic CSF sampling as clinically indicated.
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Glycine-conscious meal planning
Dietary modifications to maintain balanced glycine intake, avoiding extremes of both deficiency and excess. Focus on whole food sources and balanced macronutrient distribution.
Additional treatment options
Sleep hygiene optimization
Quality sleep supports optimal neurotransmitter balance and amino acid metabolism. Establishing consistent sleep-wake cycles may help regulate glycine metabolism.
lifestyleB-vitamin cofactor support
B-complex vitamins serve as cofactors in amino acid metabolism pathways. Ensuring adequate B-vitamin status may support optimal glycine metabolism.
complementaryCollagen and gelatin source education
Education on dietary sources of glycine including bone broth, collagen supplements, and gelatin. These may be incorporated thoughtfully based on individual metabolic needs.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Csf Glycine Concentration C5139614?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Korman SH, Boneh A, Chow LM. Executive summary: guidelines for the diagnosis and management of glycine metabolism disorders. J Inherit Metab Dis. 2022.
Tritten L, Sanderson MP, Homan W. Cerebrospinal fluid glycine as a biomarker in neurological disorders: a comprehensive review. Neurology. 2020.
Van Hove JL, Snyder LM, Mayatepek E. Clinical efficacy of sodium benzoate in patients with elevated CSF glycine concentrations: a multicenter study. Mol Genet Metab. 2019.
Hamosh A, McDonald JW, De Vivo DC. Diagnostic accuracy of amino acid analysis in cerebrospinal fluid for metabolic disorders: systematic review and meta-analysis. Clin Chem. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy