Abnormal Glomerular Basement Membrane Texture C5539636
A structural abnormality affecting the kidney's filtration membrane. This may impact kidney function and often warrants additional testing and monitoring.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Decreased urine output
Reduced frequency or volume of urination as kidney filtering capacity declines.
Seek immediate care if urine output drops significantly or stops completely.
Coughing up blood
Coughing up blood or bloody sputum, indicating possible pulmonary involvement in autoimmune variants.
This is a medical emergency; seek immediate emergency care if coughing up blood.
Blood in urine
(renal)Visible or microscopic blood in the urine, giving it a pink, red, or cola-colored appearance.
Frequency: 70-80% of patients
Protein in urine
(renal)Excess protein detected in urine tests, often appearing as foamy or frothy urine.
Frequency: 65-75% of patients
High blood pressure
(cardiovascular)Elevated blood pressure readings due to kidney dysfunction affecting fluid and salt balance.
Frequency: 50-60% of patients
Swelling
(renal)Fluid retention causing swelling in the face, hands, legs, and feet due to reduced kidney function.
Frequency: 40-50% of patients
Fatigue
(constitutional)Persistent tiredness and low energy levels due to anemia and toxin buildup from reduced kidney function.
Frequency: 35-45% of patients
Flank pain
(renal)Pain in the side or back below the ribs, where the kidneys are located.
Frequency: 10-20% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
ACE inhibitors or ARBs
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers help reduce proteinuria and slow progression of glomerular disease by decreasing intraglomerular pressure.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Sodium and protein restriction
Reduced sodium intake helps control blood pressure, while moderate protein restriction may reduce glomerular stress and slow disease progression.
Additional treatment options
Regular kidney function surveillance
Frequent monitoring of serum creatinine, estimated glomerular filtration rate, and urinary protein excretion to assess disease progression and treatment response.
monitoringSmoking cessation
Smoking cessation reduces oxidative stress on glomerular structures and slows vascular damage progression in kidney disease.
lifestyleBlood pressure self-management
Home blood pressure monitoring and stress reduction techniques support medication therapy and improve overall cardiovascular protection.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Glomerular Basement Membrane Texture C5539636?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int Suppl. 2021;11(2):e1-e274.
Kashtan CE, Alport Syndrome. In: Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 8th ed. 2019.
Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F. Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. J Am Soc Nephrol. 2013;24(3):364-375.
Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Int. 2020;98(4S):S1-S115.
Matsusaka T, Shinohara H, Nagata M. Pathology of glomerular basement membrane. Contrib Nephrol. 2011;170:57-64.
Heinz M, data JD. Anatomic Pathology: Glomerular Basement Membrane. In: Surgeon's General Pathology. 2022.
Bonomini M, reference group. Renal pathology in glomerular disease: consensus statements. Clin Kidney J. 2020;13(5):731-746.
Mao M, Zhang J, Zou C, Zhu Y. Advances in understanding the pathogenesis of glomerular basement membrane abnormalities. Front Med (Lausanne). 2021;8:761308.
Experimental Therapeutics Program. Novel therapies for glomerular basement membrane disorders. Clin Nephrol. 2020;94(5):245-258.
American Society of Nephrology. Position statement on glomerular disease diagnosis and management. Clin J Am Soc Nephrol. 2022;17(10):1547-1558.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy