Abnormal Hdl3b Concentration C5139338
Abnormal levels of HDL3b, a specific subtype of protective cholesterol particles. Variations may reflect genetic or metabolic factors. Healthcare providers typically address this through comprehensive heart disease prevention strategies.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Jaundice
Yellowing of the skin and whites of the eyes indicating possible liver involvement or bile duct issues.
Seek immediate medical attention if jaundice appears, as it may indicate a serious underlying condition.
Severe Chest Pain
Intense, crushing chest pain that may radiate to the arm, jaw, or back, potentially indicating a cardiac event.
Call emergency services immediately if experiencing severe chest pain, as it may indicate a heart attack.
Unexplained Fatigue
(constitutional)Persistent tiredness and lack of energy that does not improve with rest, often related to impaired lipid metabolism and energy utilization.
Frequency: 70-80% of patients
Chest Discomfort
(cardiovascular)Mild pressure, tightness, or aching in the chest area that may occur during physical activity or at rest.
Frequency: 40-50% of patients
Shortness of Breath
(respiratory)Difficulty breathing or feeling winded with minimal exertion, potentially due to cardiovascular strain from lipid abnormalities.
Frequency: 35-45% of patients
Leg Swelling
(cardiovascular)Puffiness or swelling in the lower legs and ankles due to fluid buildup from compromised circulation.
Frequency: 30-40% of patients
Skin Xanthomas
(dermatologic)Yellowish, fatty deposits that appear as bumps on the skin, typically around tendons in hands, elbows, or knees.
Frequency: 10-15% of patients
Abdominal Discomfort
(gastrointestinal)Vague pain or fullness in the abdominal region, sometimes associated with liver involvement from lipid metabolism disturbances.
Frequency: 15-20% of patients
Mild Cognitive Fog
(neurologic)Difficulty with concentration, brain fog, or mild memory issues that may be linked to cerebral vascular changes.
Frequency: 15-20% of patients
Arcus Corneae
(dermatologic)A grayish or white ring appearing around the cornea of the eye due to lipid deposition.
Frequency: 5-10% of patients
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Plant Sterol and Stanol Supplementation
Incorporation of plant sterols or stanols into the diet through fortified foods or supplements helps optimize HDL3b subfraction concentrations by competing with cholesterol absorption in the intestine.
Weight Management Program
Achieving and maintaining healthy body weight through balanced nutrition and regular physical activity positively influences HDL3b subfraction levels and improves overall lipid metabolism.
Additional treatment options
Polyphenol-Rich Food Consumption
Regular consumption of polyphenol-rich foods including berries, dark chocolate, green tea, and red wine in moderation provides antioxidant benefits that protect HDL3b particles from oxidative damage.
complementaryFasting Lipid Profile Follow-up
Serial monitoring of fasting lipid panels including detailed subfraction analysis to track HDL3b response to interventions and guide treatment decisions over time.
monitoringSaturated Fat Reduction
Limiting intake of saturated fats from red meat, full-fat dairy products, and processed foods while replacing with unsaturated fat sources helps maintain healthy HDL3b subfraction levels.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Abnormal Hdl3b Concentration C5139338?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
Gordon SM, Davidson WS. Apolipoprotein A-I mimetics and high-density lipoprotein function. Curr Opin Lipidol. 2018;29(4):285-292.
Feingold KR, Grunfeld C. Introduction to Lipids and Lipoproteins. In: Endotext [Internet]. MDText.com, Inc.; 2020.
Rashid S, Tavori H, Brown PE, et al. High-density lipoprotein subfractions in clinical practice: The emerging paradigm. J Am Coll Cardiol. 2018;72(12):1404-1418.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J. 2020;41(1):111-188.
Liu C, Dhindsa D, Almuwaqqat Z, et al. Association between high-density lipoprotein subspecies and incident cardiovascular events: A systematic review and meta-analysis. Circulation. 2022;145(8):602-615.
Kontush A, Chapman MJ. High-density lipoproteins: Structure, function, and metabolism. In: Ballantyne CM, editor. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 3rd ed. Elsevier; 2020:45-62.
Toth PP, Grabner M, Punekar RS, et al. Cardiovascular risk in patients achieving low-density lipoprotein cholesterol and high-density lipoprotein cholesterol targets. J Clin Lipidol. 2019;13(5):765-774.
Jacobson TA, Maki KC, Orringer CE, et al. National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. J Clin Lipidol. 2015;9(6):S1-S122.e1.
Bhate V, Bhate A, Sangle N. HDL subfractions and cardiovascular disease: Current understanding and future directions. Ann Natl Acad Med Sci. 2022;58(1):23-35.
Medication Comparisons
Compare medications used to treat Abnormal Hdl3b Concentration C5139338. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy