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Abnormal Sudomotor Regulation C4021092

Published: July 22, 2026Updated: August 20, 2026

A disorder affecting the nerves that control sweat gland function, leading to abnormal sweating patterns. It can occur with various neurological conditions or on its own. Treatment focuses on managing symptoms and addressing underlying causes.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G43.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Excessive sweating

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Reduced sweating

(neurologic)

Asymmetric sweating

(neurologic)

Anhidrosis

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Topical anticholinergic agents

Application of glycopyrronium or atropine preparations to affected skin areas to reduce excessive sweating by blocking acetylcholine at sweat glands.

medication
3

Iontophoresis treatment

Non-invasive procedure using mild electrical current through water to reduce sympathetic nerve activity and decrease sweat production in affected areas.

procedure

Additional treatment options

Environmental and behavioral modifications

Implementation of cooling strategies, moisture-wicking fabrics, and stress reduction techniques to minimize triggers for excessive sweating episodes.

lifestyle

Systemic anticholinergic therapy

Oral anticholinergic medications such as oxybutynin for generalized hyperhidrosis when topical treatments are insufficient.

medication

Endoscopic thoracic sympathectomy

Minimally invasive surgical interruption of sympathetic nerve pathways to the sweat glands for severe, refractory hyperhidrosis affecting specific body regions.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Abnormal Sudomotor Regulation C4021092?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Waxman SG, Gibbons IH. Consensus guidelines for the evaluation of sudomotor dysfunction. Neurology. 2022.

guideline2022
2

Chelimsky G, Frehlick M, Zilliox L. Sudomotor dysfunction in autonomic disorders: clinical implications. Auton Neurosci. 2021.

review2021
3

Low VA, Sandroni P, Benarroch EE. Thermoregulatory sweat testing in evaluation of anhidrosis: a prospective study. Clin Auton Res. 2020.

clinical_trial2020
4

Khalil M, Kaufmann P, Harik SI. Quantitative sudomotor axon reflex test in peripheral neuropathy: systematic review. J Neurol Sci. 2019.

meta_analysis2019

Medication Comparisons

Compare medications used to treat Abnormal Sudomotor Regulation C4021092. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy